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Intralesional pentoxifylline as an adjuvant treatment for perioral post-burn hypertrophic scars.
MedLine Citation:
PMID:  20064692     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Pentoxifylline (PTF), a methylxanthine derivative, has therapeutic use as an antifibrotic agent. In vitro, PTF inhibits the production of collagen and reduces the proliferation of fibroblasts in hypertrophic scars. This study aimed to evaluate changes in the elasticity of hypertrophic scars in the peribuccal area in burned patients, who presented with mouth-opening limitation. Eighteen patients were divided into two groups. The case group (n=10) was treated with PTF 1 mg ml(-1), while in the control group (n=8) no treatment was performed. Measurements of mouth opening (lip-to-lip and tooth-to-tooth distances in mm) were taken, before and after five therapeutic sessions with pentoxifylline with weekly intervals. The variations of these measures (Delta%) were calculated and submitted to statistical analyses. There was a significant improvement in the opening of the mouth, in vermilion distance (V=3.20 mm) as much as the dental distance (DD=4.19 mm) in the treated group, than in the control group. It was noted that pentoxifylline increases the elasticity of hypertrophic scars in the perioral area.
Authors:
Cesar Isaac; Viviane Fernandes Carvalho; André Oliveira Paggiaro; Mauricio de Maio; Marcus Castro Ferreira
Publication Detail:
Type:  Journal Article     Date:  2010-01-12
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  36     ISSN:  1879-1409     ISO Abbreviation:  Burns     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  831-5     Citation Subset:  IM    
Copyright Information:
2009 Elsevier Ltd and ISBI. All rights reserved.
Affiliation:
Faculty of Medicine, Cell Culture and Wound Healing Research Laboratory, Division of Plastic Surgery, University of São Paulo, Avenida Doutor Arnaldo 455 Sala 1360, São Paulo, Brazil. cesaris@plastica.fm.usp.br
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