Document Detail

Intralesional interferon alfa-2b treatment of keratoacanthomas.
MedLine Citation:
PMID:  15577764     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Complete excision is not always easy when a keratoacanthoma is large or located in certain anatomic areas. An effective nonsurgical treatment would be desirable in such cases. OBJECTIVE: This was a pilot study of the effects of intralesional interferon alfa-2b in the treatment of rapidly growing keratoacanthomas. METHODS: A total of 4 large, rapidly growing keratoacanthomas, which were located on the lower lip, neck, and cheeks of the 4 different patients, were treated with intralesional interferon alfa-2b injection weekly. Serial photographs were taken to observe the course of responses. RESULTS: All lesions resolved completely in 5 to 7 weeks with acceptable cosmetic results. CONCLUSION: Intralesional interferon alfa-2b can be a treatment modality of these difficult lesions.
Chang-Keun Oh; Hyo-Sung Son; Jae-Bong Lee; Ho-Sun Jang; Kyung-Sool Kwon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  51     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-03-25     Revised Date:  2005-06-24    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S177-80     Citation Subset:  IM    
Department of Dermatology, Pusan National University College of Medicine, Busan, Korea.
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MeSH Terms
Chills / chemically induced
Fever / chemically induced
Follow-Up Studies
Injections, Intralesional / adverse effects
Interferon Alfa-2b / administration & dosage*,  adverse effects
Keratoacanthoma / drug therapy*
Lip Diseases / drug therapy*
Middle Aged
Pain / etiology
Pilot Projects
Reg. No./Substance:
99210-65-8/Interferon Alfa-2b
Erratum In:
J Am Acad Dermatol. 2004 Dec;51(6):1040

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