Document Detail


Intralesional injection of pingyangmycin is a safe and effective treatment for microcystic lymphatic malformations in the tongue.
MedLine Citation:
PMID:  22378834     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the efficacy and safety of intralesional injection of pingyangmycin for the treatment of microcystic lymphatic malformations (LMs) in the tongue. METHODS: Eighteen patients with tongue microcystic LMs were treated with intralesional injection of pingyangmycin. The concentration of the drug was 1 mg/mL with an addition of dexamethasone. Repeated injections were performed at an interval of 3-4 weeks. The results were evaluated by clinical examinations and Doppler ultrasonography scan. The follow-up period was 12 months to eight years after the last treatment and the mean follow-up time was three years. All patients received 1-8 injections (mean, 3.0 injections) for the whole course of treatment. The total dose of pingyangmycin administered was 8-64 mg (mean, 24 mg). RESULTS: Fifteen patients had complete response with no cosmetic or functional problems. Three patients with macroglossia had a reduction of 50-90% in the lesion size and needed secondary surgery. No serious complications were encountered. CONCLUSION: The results suggested that intralesional injection of pingyangmycin is an effective and safe treatment for microcystic LMs in the tongue, and can be used as the first-line treatment protocol.
Authors:
H M Mai; J W Zheng; Q Zhou; X J Yang; Y A Wang; X D Fan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-29
Journal Detail:
Title:  Phlebology / Venous Forum of the Royal Society of Medicine     Volume:  -     ISSN:  1758-1125     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012921     Medline TA:  Phlebology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China.
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