| Intralesional injection of pingyangmycin is a safe and effective treatment for microcystic lymphatic malformations in the tongue. | |
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MedLine Citation:
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PMID: 22378834 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy and safety of intralesional injection of pingyangmycin for the treatment of microcystic lymphatic malformations (LMs) in the tongue. METHODS: Eighteen patients with tongue microcystic LMs were treated with intralesional injection of pingyangmycin. The concentration of the drug was 1 mg/mL with an addition of dexamethasone. Repeated injections were performed at an interval of 3-4 weeks. The results were evaluated by clinical examinations and Doppler ultrasonography scan. The follow-up period was 12 months to eight years after the last treatment and the mean follow-up time was three years. All patients received 1-8 injections (mean, 3.0 injections) for the whole course of treatment. The total dose of pingyangmycin administered was 8-64 mg (mean, 24 mg). RESULTS: Fifteen patients had complete response with no cosmetic or functional problems. Three patients with macroglossia had a reduction of 50-90% in the lesion size and needed secondary surgery. No serious complications were encountered. CONCLUSION: The results suggested that intralesional injection of pingyangmycin is an effective and safe treatment for microcystic LMs in the tongue, and can be used as the first-line treatment protocol. |
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Authors:
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H M Mai; J W Zheng; Q Zhou; X J Yang; Y A Wang; X D Fan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-29 |
Journal Detail:
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Title: Phlebology / Venous Forum of the Royal Society of Medicine Volume: - ISSN: 1758-1125 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012921 Medline TA: Phlebology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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