| Intralesional BCG application in malignant melanoma. | |
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MedLine Citation:
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PMID: 794745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunotherapy of malignant melanoma with BCG may be divided into two basic groups: 1. treatment of minimum residual disease. 2. direct intralesional application of BCG. In 19 patients with a histologically confirmed malignant melanoma, direct intralesional application of BCG was used to treat relapsing patients. In 10 of the 19 patients (group A) the relapse was confined to the primary region without signs of distant dissemination. In the remaining 9 patients (group B) signs of the lesion were present prior to BCG application. Our clinical and cytological evaluation bore on local reactions, systemic side reactions and response of non-injected lesions. In patients without signs of distant dissemination, local regression, characterized by a flattening and disappearance of lenticular metastases with scar formation, was achieved in 8/10 patients, while in the noninjected lesions, regression was noted in only 4/10 patients. In 4 patients of group A complete remission lasting 4-6 months was achieved. In the group of patients with signs of distant dissemination, local regression was observed in 6/9, while noninjected lesion regressed in only 1/9. Systemic response to BCG was characterized by febrile reactions with, in the majority of the patients, nausea till vomiting, muscular pain, pain of joints. In the majority of the patients the reaction passed away within 24 hr. A pretreatment with antipyretic and antihistaminic drugs proved of great help. The effect of BCG on the subsequent fate and survival of the patients is not discussed. |
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Authors:
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B Sopková; V Kolár |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neoplasma Volume: 23 ISSN: 0028-2685 ISO Abbreviation: Neoplasma Publication Date: 1976 |
Date Detail:
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Created Date: 1977-02-24 Completed Date: 1977-02-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 421-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical BCG Vaccine* Humans Immunotherapy Injections Melanoma / therapy* Mycobacterium bovis / immunology* Neoplasm Metastasis Remission, Spontaneous Skin Neoplasms / therapy* |
| Chemical | |
Reg. No./Substance:
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0/BCG Vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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