| Intralesional Antimony for single lesions of Bolivian cutaneous leishmaniasis. | |
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MedLine Citation:
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PMID: 23390069 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. Cutaneous leishmaniasis is an ultimately self-curing disease for which systemic therapy with pentavalent antimony (Sb) is effective but with side effects. We evaluated two local treatments, intralesional Sb (Il Sb) and cryotherapy, for single lesions due to Bolivian L v braziliensis in a placebo-controlled study.Methods. Patients were randomized between Il Sb (650 ug/mm2 of lesion area on days 1, 3, and 5), cryotherapy (days 1 and 14), and placebo cream (daily for 20 days) in 3:2:3 allocation. Lesion area was measured prior to therapy, and at 1, 3, and 6 months after therapy. The criteria for lesion cure were not doubling in size at 1 month, at least 50% diminution in size at 3 months, and complete re-epithelialization at 6 months. Local adverse effects were recorded.Results. Cure rates were 21 of 30 (70%: 52-83%) for IL Sb, 4 of 20 (20%: 8-42%) for cryotherapy, and 5 of 30 (17%: 7-34%) for placebo cream: P<0.001 for Il Sb vs each other group. Il Sb adverse events were limited to injection site pain, with a mean value of 1.0 (mild).Conclusions. The comparative cure rate, small amount of drug administered, and tolerance data for Il Sb suggest that if local therapy for single L braziliensis lesions is chosen, this treatment is attractive. Given the difficulties of performing placebo-controlled trials in the New World, the combined placebo and cryotherapy cure rate (18%: 10-31%) is likely to become the standard against which future interventions for L braziliensis are compared. |
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Authors:
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Jaime Soto; Ernesto Rojas; Miguel Guzman; Aleida Verduguez; Winne Nena; Maria Maldonado; Mary Cruz; Lineth Gracia; Darsi Villarroel; Isidoro Alavi; Julia Toledo; Jonathan Berman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-6 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: - ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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FUNDERMA (Fundación Nacional de Dermatología), Santa Cruz, Bolivia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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