Document Detail

Intralesional 5-fluorouracil in the treatment of keloid scars.
MedLine Citation:
PMID:  15068466     Owner:  NLM     Status:  MEDLINE    
Two patients with keloid scars are described. The first patient presented with extensive keloid scarring on both cheeks secondary to acne. The second patient developed a keloid scar on her chest following excision of a mole. Both patients' scars were diagnosed clinically and treated with fortnightly injections of a mixture of 5-fluorouracil and betamethasone acetate and betamethasone sodium phosphate. At each injection session up to 1.6 mL of 5-fluorouracil at a concentration of 500 mg/10 mL and 0.4 mL of betamethasone acetate and betamethasone sodium phosphate (as betamethasone acetate 3 mg in suspension and betamethasone sodium phosphate 3.9 mg in solution) were used. Multiple treatments were required to obtain resolution of the keloid scars. Improvement was maintained in both patients at 1 year post treatment.
Martine Apikian; Greg Goodman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Australasian journal of dermatology     Volume:  45     ISSN:  0004-8380     ISO Abbreviation:  Australas. J. Dermatol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0135232     Medline TA:  Australas J Dermatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  140-3     Citation Subset:  IM    
Specialist Cosmetic Laser Clinic, 8th Floor, Trak Centre, 445 Toorak Road, Toorak 5142, Melbourne, Victoria, Australia.
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MeSH Terms
Acne Keloid / drug therapy
Antimetabolites / administration & dosage,  therapeutic use*
Betamethasone / administration & dosage,  analogs & derivatives*,  therapeutic use
Facial Dermatoses / drug therapy
Fluorouracil / administration & dosage,  therapeutic use*
Follow-Up Studies
Glucocorticoids / administration & dosage,  therapeutic use
Injections, Intralesional
Keloid / drug therapy*
Reg. No./Substance:
0/Antimetabolites; 0/Glucocorticoids; 151-73-5/betamethasone sodium phosphate; 378-44-9/Betamethasone; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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