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Intraindividual comparison of gadolinium- and iodine-enhanced 64-slice multidetector CT pulmonary angiography for the detection of pulmonary embolism in a porcine model.
MedLine Citation:
PMID:  21136130     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study is an evaluation of the diagnostic accuracy of gadolinium-enhanced computed tomography pulmonary angiography (CTPA) for the detection of pulmonary embolism (PE) in comparison with iodine-enhanced CTPA. PE was induced in five anesthetized pigs by administration of blood clots through an 11-F catheter inside the jugular vein. Animals underwent CTPA in breathhold with i.v. bolus injection of 50 ml gadopentetate dimeglumine (0.4 mmol/kg, 4 ml/s). Subsequently, CTPA was performed using the same imaging parameters but under administration of 70 ml nonionic iodinated contrast material (400 mg/ml, 4 ml/s). All images were reconstructed with 1 mm slice thickness. A consensus readout of the iodium-enhanced CTPAs by both radiologists served as reference standard. Gadolinium-enhanced CTPAs were evaluated independently by two experienced radiologists, and differences in detection rate between both contrast agents were assessed on a per embolus basis using the Wilcoxon signed-rank test. Interobserver agreement was determined by calculation of қ values. PE was diagnosed independently by both readers in all five pigs by the use of gadolinium-enhanced CTPA. Out of 60 pulmonary emboli detected in the iodine-enhanced scans, 47 (78.3%; reader 1) and 44 (62.8%; reader 2) emboli were detected by the use of gadolinium. All 13 (100%) emboli in lobar arteries (by both readers) and 26 (reader 1) and 25 (reader 2) out of 27 emboli (96.3% and 92.6%) in segmental arteries were detected by the use of the gadolinium-enhanced CTPA. In subsegmental arteries, only 8 (40%; reader 1) and 6 (30%; reader 2) out of 20 emboli were detected by the gadolinium-enhanced CTPA. By comparing both scans on a per vessel basis (Wilcoxon test), Gd-enhanced CTPA was significantly inferior in emboli detection on subsegmental level (P < 0.0001). The interobserver agreement was excellent on lobar and segmental level (қ = 1.0 and 0.93, respectively), whereas readers only reached moderate agreement for PE evaluation on subsegmental level (қ = 0.56). Compared to conventional CTPA with iodinated contrast media, gadolinium-based contrast agents achieve an equivalent diagnostic accuracy in detection of PE down to segmental level. Gadolinium-enhanced CTPA may be considered as an alternative for the diagnostic workup of acute pulmonary embolism in patients with contraindications to iodinated contrast agents.
Authors:
Frank Oliver Gerhard Henes; Michael Groth; Philipp G C Begemann; Gerhard Adam; Marc Regier
Publication Detail:
Type:  Journal Article     Date:  2010-12-07
Journal Detail:
Title:  Emergency radiology     Volume:  18     ISSN:  1438-1435     ISO Abbreviation:  Emerg Radiol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431227     Medline TA:  Emerg Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
Affiliation:
Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany, f.henes@uke.uni-hamburg.de.
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