| Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alfa-2a and adefovir. | |
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MedLine Citation:
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PMID: 21557773 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: We investigated whether intrahepatic markers could predict response in chronic hepatitis B patients treated with peg-IFN and adefovir for 48 weeks. Methods: Intrahepatic cccDNA, total intrahepatic HBV DNA and the proportion of HBsAg and HBcAg positive hepatocytes in 16 HBeAg positive and 24 HBeAg negative patients were measured at baseline and at the end of treatment. Results: Baseline intrahepatic markers were not associated with sustained virological response (SVR) defined as HBV DNA <2,000 IU/mL and persistent normal ALT levels at the end of follow-up (week 72). At the end of treatment, intrahepatic cccDNA and total intrahepatic HBV DNA in HBeAg positive patients were significantly lower in patients with HBeAg seroconversion (p = 0.016 and p = 0.010) with positive predictive values (PPV) for SVR of 80% and 80% respectively. In HBeAg negative patients, intrahepatic cccDNA and total intrahepatic HBV DNA had declined significantly at end of treatment (p = 0.035 and p = 0.041) and corresponding PPV for SVR was 73% and 82%. In HBeAg positive patients, median proportion of HBcAg positive hepatocytes declined significantly (p = 0.002) at end of treatment. In HBeAg negative patients, the proportion of HBsAg positive hepatocytes had declined significantly at the end of treatment (p = 0.0009). Using HBsAg ≤ 7.5% as limit, PPV for SVR in HBeAg negative patients was 83%. Conclusions: At end of treatment in HBeAg positive patients, intrahepatic cccDNA and total intrahepatic HBV DNA were predictive for SVR. In HBeAg negative patients a proportion of <7.5% HBsAg positive hepatocytes at end of treatment was a strong predictor for SVR. |
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Authors:
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R B Takkenberg; V Terpstra; H L Zaaijer; C J Weegink; M G W Dijkgraaf; P L M Jansen; M G H M Beld; H W Reesink |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-9 |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: - ISSN: 1440-1746 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Medical Microbiology and Landsteiner Laboratory, Academic Medical Center, Center for Infectious Disease and Immunology (CINIMA), University of Amsterdam, Amsterdam, the Netherlands. Clinical Research Unit, Academic Medical Center, University of Amsterdam, the Netherlands. Royal Tropical Institute, KIT Biomedical Research, Amsterdam, the Netherlands. |
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