| Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice. | |
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MedLine Citation:
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PMID: 20114046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatic inflammation is the key factor in non-alcoholic steatohepatitis (NASH) and promotes progression to liver damage. We recently identified dietary cholesterol as the cause of hepatic inflammation in hyperlipidemic mice. We now show that hepatic transcriptome responses are strongly dependent on cholesterol metabolism during diet-induced NASH and its inhibition by fenofibrate. Furthermore, we show that, despite doubling hepatic steatosis, pharmacological LXR activation reverses hepatic inflammation, in parallel with reversing hepatic cholesterol levels. Together, the results indicate a prominent role of cholesterol during the development, inhibition and reversal of hepatic inflammation in NASH and reveal potential new therapeutic strategies against NASH. |
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Authors:
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Kristiaan Wouters; Marc van Bilsen; Patrick J van Gorp; Veerle Bieghs; Dieter L?tjohann; Anja Kerksiek; Bart Staels; Marten H Hofker; Ronit Shiri-Sverdlov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-29 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-23 Completed Date: 2010-03-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1001-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Molecular Genetics, Institutes of Maastricht University Maastricht, Maastricht, The Netherlands. kristiaan.wouters@inserm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / metabolism* Dietary Fats / adverse effects* Disease Models, Animal Fatty Liver / chemically induced, metabolism*, pathology* Gene Expression Regulation Liver / metabolism*, pathology* Mice Mice, Mutant Strains |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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