Document Detail

Intrahepatic cholestasis with parental alimentation.
MedLine Citation:
PMID:  814824     Owner:  NLM     Status:  MEDLINE    
From July 1971 to March 1975, elevan infants receiving total or partial parenteral alimentation at the University of Florida showed histologic evidence of intrahepatic cholestasis. The clinical records of these patients have been examined. These infants were critically ill and had protracted hospital courses with only two survivors. Liver biopsies demonstrated marked cholestasis with some fibrosis and thickening of the limiting membrane of the hepatocyte. In those patients in whom serial liver biopsies were obtained, hepatic histology returned toward normal, paralleling improvement in liver function studies, as intravenous alimentation was discontinued. Careful monitoring of the liver function tests is essential to detect this progressive abnormality as early as possible and discontinue intravenous alimentation. Follow-up as long as two and a half years in the two surviving patients has demonstrated no chronic dysfunction.
B M Rodgers; J I Hollenbeck; W H Donnelly; J L Talbert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  131     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-10     Completed Date:  1976-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  AIM; IM    
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MeSH Terms
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Bile Ducts, Intrahepatic / pathology*
Cholestasis / enzymology,  etiology*,  pathology
Hyperbilirubinemia / etiology
Infant, Newborn
Infant, Premature, Diseases / etiology
Liver / enzymology,  pathology
Liver Cirrhosis / pathology
Parenteral Nutrition / adverse effects*
Reg. No./Substance:
EC Aminotransferases; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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