| Intrahepatic cholestasis of pregnancy: a past and present riddle. | |
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MedLine Citation:
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PMID: 17060884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disorders that occurs mainly in the third trimester of pregnancy and is characterized by pruritus and elevated bile acid levels. ICP is regarded as a benign disease with no meaningful consequences to the mother but associated to an increased perinatal risk with increased rates of fetal morbidity and mortality. The pathogenesis of disease is unknown but likely involves a genetic hypersensitivity to estrogen or estrogen metabolites. Mutations or polymorphisms of some hepatobiliary transport proteins may contribute to disease pathogenesis or severity. Treatment is focused on a) reducing symptoms in the mother and b) to provide an adequate obstetric management in order to prevent fetal distress. Currently, only Ursodeoxycholic acid treatment has been proven to be useful and should be considered mainly in patients with severe pruritus or complications in previous pregnancies. |
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Authors:
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Marco Arrese; Humberto Reyes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of hepatology Volume: 5 ISSN: 1665-2681 ISO Abbreviation: Ann Hepatol Publication Date: 2006 Jul-Sep |
Date Detail:
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Created Date: 2006-10-24 Completed Date: 2007-05-24 Revised Date: 2013-05-16 |
Medline Journal Info:
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Nlm Unique ID: 101155885 Medline TA: Ann Hepatol Country: Mexico |
Other Details:
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Languages: eng Pagination: 202-5 Citation Subset: IM |
Affiliation:
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Departamento de Medicina, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. marrese@med.puc.cl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholagogues and Choleretics
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therapeutic use Cholestasis, Intrahepatic / drug therapy, epidemiology, genetics, physiopathology* Female Humans Pregnancy* Pregnancy Complications* Ursodeoxycholic Acid / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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