Document Detail

Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems.
MedLine Citation:
PMID:  18855975     Owner:  NLM     Status:  MEDLINE    
Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disorder. Maternal effects of ICP are mild; however, there is a clear association between ICP and higher frequency of fetal distress, preterm delivery, and sudden intrauterine fetal death. The cause of ICP remains elusive, but there is evidence that mutations in genes encoding hepatobiliary transport proteins can predispose for the development of ICP. Recent data suggest that ursodeoxycholic acid is currently the most effective pharmacologic treatment, whereas obstetric management is still debated. Clinical trials are required to identify the most suitable monitoring modalities that can specifically predict poor perinatal outcome. This article aims to review current achievements and unsolved problems of ICP.
Jurate Kondrackiene; Limas Kupcinskas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  14     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2009-04-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5781-8     Citation Subset:  IM    
Department of Gastroenterology, Kaunas University of Medicine, Kaunas 50009, Lithuania.
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MeSH Terms
Cholestasis, Intrahepatic* / diagnosis,  epidemiology,  etiology,  therapy
Diagnosis, Differential
Pregnancy Complications* / diagnosis,  epidemiology,  etiology,  therapy
Pregnancy Outcome
Risk Factors
Treatment Outcome

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