| Intrahepatic cholestasis of pregnancy: Correlation of preterm delivery with bile acids. | |
| | |
MedLine Citation:
|
PMID: 22287405 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background/aims: The aim of this study was to determine the incidence, obstetrical and fetal complication rates of intrahepatic cholestasis of pregnancy in patients managed actively around 38 weeks and evaluate the correlation of these results with liver function tests and bile acids. Material and Methods: In this cohort study 3710 women were booked for delivery, of which 32 pregnant women were diagnosed as intrahepatic cholestasis of pregnancy. All data concerning obstetric- medical history, laboratory results, symptom onset time, pruritus degree, treatment response, and delivery time and infants information were recorded in the study protocol. Statistical analyses were conducted with SPSS 12.0 version and correlations were assessed by Spearman Rank correlation analysis. Results: The incidence of intrahepatic cholestasis of pregnancy was 0.86%. The symptoms appeared around 32 weeks. 16.6% multiparas had a previously affected pregnancy and 21.8% of intrahepatic cholestasis of pregnancy patients had family history of intrahepatic cholestasis of pregnancy. Symptom onset varied according to season (p<0.05). Most patients (69.5%) were diagnosed in winter and the beginning of spring. There were no reported cases of clinical maternal jaundice, bleeding tendency or stillbirth. Pruritus was decreased by ursodeoxycholic acid treatment. Total bile acids tended to be higher in patients with preterm delivery (r=0.409, p=0.038). Conclusion: Total bile acids are correlated with preterm delivery. An attempt to deliver at around 38 weeks may improve perinatal outcome. |
| | |
Authors:
|
Ozlem Pata; Eser Vardarelı; Alihan Ozcan; Mustafa Serteser; Ibrahim Unsal; Murat Saruç; Cihat Unlü; Nurdan Tözün |
Related Documents
:
|
22382655 - Pelvic floor muscle strength predicts stress urinary incontinence in primiparous women ... 22375705 - Urinary steroid profile in early pregnancy after in vitro fertilization. 16601595 - The risk of neuro-orthopaedic malformations following in-vitro fertilization. 14712155 - Job strain and male fertility. 10368485 - Ultrasonographic assessment of cervical length in triplet pregnancies. 19204745 - A survey of the current use of anti-d immunoprophylaxis and the incidence of haemolytic... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology Volume: 22 ISSN: 1300-4948 ISO Abbreviation: Turk J Gastroenterol Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-01-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9515841 Medline TA: Turk J Gastroenterol Country: Turkey |
Other Details:
|
Languages: eng Pagination: 602-5 Citation Subset: IM |
Affiliation:
|
Acıbadem University, Department of Obstetric and Gynecology, İstanbul, Turkey. ozpata@yahoo.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acut...
Next Document: Serum iron parameters in cirrhosis and chronic hepatitis: Detailed description.