Document Detail


Intrahepatic biliary cystadenocarcinoma: clinical analysis of 4 cases.
MedLine Citation:
PMID:  19208519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intrahepatic biliary cystadenocarcinoma (IBC) is a low-incidence disease which is often misdiagnosed because of insufficient recognition. This study aimed to investigate the clinical features, diagnosis and treatment of the disease. METHOD: The clinical data of 4 IBC patients treated in the Second Affiliated Hospital of Sun Yat-Sen University were retrospectively analyzed. RESULTS: The 4 patients complained of right upper abdominal pain and mass or masses. One patient presented with moderate fever and chills, and two had moderately impaired liver function. The levels of carbohydrate antigens (CA125 and CA19-9) were significantly elevated and the level of carcinoembryonic antigen was slightly elevated in 3 patients. The level of serum transaminase was elevated in 2 patients, and the level of serum total bilirubin elevated in 2. Intrahepatic cystic masses ranging from 5.0 to 20.5 cm in diameter were found in all patients by ultrasound and CT/MR scan. Three of the 4 patients were misdiagnosed on admission as having hepatic cyst and one as having hepatic abscess. Radical removal of masses was performed in three patients after pathological diagnosis. One patient died from tumor recurrence 7 years after operation, 2 were followed up for 12 and 17 months without evidence of recurrence. The high risk patients who received palliative therapy were closely followed up. CONCLUSIONS: The diagnosis of IBC without specific clinical features mainly depends on imaging and pathological examination. Increased levels of serum CA125 and CA19-9 might contribute to the diagnosis and prognosis of some IBC patients. Radical excision is the only effective treatment.
Authors:
Qiang Yu; Tao Chen; Yun-Le Wan; Jun Min; Yu Cheng; Hua Guo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  8     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bile Ducts, Intrahepatic / pathology*
Biliary Tract Neoplasms / pathology*,  surgery*
Bilirubin / blood
Cystadenocarcinoma / pathology*,  surgery*
Cysts / pathology
Fatal Outcome
Female
Humans
Liver Function Tests
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Recurrence, Local / pathology
Retrospective Studies
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
635-65-4/Bilirubin

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