| Intrahepatic bile duct dilatation due to liver metastases from colorectal carcinoma. | |
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MedLine Citation:
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PMID: 19696289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of our study was to assess the association between colorectal liver metastases and intrahepatic bile duct dilatation and compare its frequency with the frequency of intrahepatic bile duct dilatation in other common noncolorectal metastases and hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A retrospective review of the radiology database was performed to obtain the records of patients who underwent CT for staging of histologically proven colorectal carcinoma (n = 1,000), noncolorectal carcinomas (n = 1,000), and HCC (n = 226). The CT scans of the 2,226 patients were reviewed for the presence of liver metastases and masses, the presence of intrahepatic bile duct dilatation directly related to the masses, the size of the largest lesion, and the associated caliber of the dilated intrahepatic bile duct. RESULTS: Of the 297 patients with colorectal liver metastases, 49 (16.5%) had intrahepatic bile duct dilatation, whereas of the 263 patients with noncolorectal liver metastases, only eight (3%) had dilated ducts. Thirteen (5.7%) of the 226 patients with HCC had intrahepatic bile duct dilatation. Intrahepatic bile duct dilatation was present in significantly more patients with colorectal liver metastases (p < 0.05) than those with noncolorectal and HCC metastases. The mean sizes of the lesions and mean caliber of the dilated bile duct from colorectal metastases, noncolorectal metastases, and HCC were 5.3, 3.9, and 5.6 cm, respectively, and 5.1, 4.6, and 4.8 mm, respectively. Overall lesion size irrespective of diagnosis had no significant correlation with the probability of bile duct dilatation (p = 0.16; odds ratio = 1.08; 95% CI, 0.97-1.20). Lesion size also did not have a significantly different effect on the probability of dilatation for the three diagnoses (p = 0.71). The caliber of bile duct dilatation did not significantly differ among the three groups of patients by diagnosis (p = 0.70). CONCLUSION: Colorectal liver metastases have a significantly higher tendency to cause intrahepatic bile duct dilatation than noncolorectal metastases and HCC due to the characteristic features, such as cholangiocarcinoma, of intrabiliary growth. This association has important diagnostic, surgical, and prognostic implications that make it necessary to highlight this finding while communicating with clinical colleagues. |
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Authors:
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Kartik S Jhaveri; Jaydeep Halankar; Diego Aguirre; Masoom Haider; Gina Lockwood; Maha Guindi; Sandra Fischer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 193 ISSN: 1546-3141 ISO Abbreviation: - Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-21 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 752-6 Citation Subset: AIM; IM |
Affiliation:
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Abdominal Imaging Division, Department of Medical Imaging, University of Toronto, University Health Network and Mount Sinai Hospital, 610 University Ave., 3-957, Toronto, ON M5G 2M9, Canada. kartik.jhaveri@uhn.on.ca |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Bile Ducts, Intrahepatic / pathology* Carcinoma, Hepatocellular / complications*, secondary* Chi-Square Distribution Colorectal Neoplasms / pathology* Contrast Media Dilatation, Pathologic / etiology, radiography Female Humans Liver Neoplasms / complications*, secondary* Logistic Models Male Middle Aged Neoplasm Staging Radiographic Image Interpretation, Computer-Assisted Retrospective Studies Tomography, X-Ray Computed* Triiodobenzoic Acids / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Triiodobenzoic Acids; 92339-11-2/iodixanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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