Document Detail


Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes.
MedLine Citation:
PMID:  23260099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To assess precision magnetic resonance imaging in the neonate and determine whether there is an early maternal influence on the pattern of neonatal fat deposition in the offspring of mothers with gestational diabetes mellitus (GDM) and obesity compared with the offspring of normal-weight women.
STUDY DESIGN: A total of 25 neonates born to normal weight mothers (n = 13) and to obese mothers with GDM (n = 12) underwent magnetic resonance imaging for the measurement of subcutaneous and intra-abdominal fat and magnetic resonance spectroscopy for the measurement of intrahepatocellular lipid (IHCL) fat at 1-3 weeks of age.
RESULTS: Infants born to obese/GDM mothers had a mean 68% increase in IHCL compared with infants born to normal-weight mothers. For all infants, IHCL correlated with maternal prepregnancy body mass index but not with subcutaneous adiposity.
CONCLUSION: Deposition of liver fat in the neonate correlates highly with maternal body mass index. This finding may have implications for understanding the developmental origins of childhood nonalcoholic fatty liver disease.
Authors:
David E Brumbaugh; Phillip Tearse; Melanie Cree-Green; Laura Z Fenton; Mark Brown; Ann Scherzinger; Regina Reynolds; Meredith Alston; Camille Hoffman; Zhaoxing Pan; Jacob E Friedman; Linda A Barbour
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-20
Journal Detail:
Title:  The Journal of pediatrics     Volume:  162     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-07-12     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  930-6.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adiposity
Adult
Body Composition
Diabetes, Gestational / physiopathology*
Fatty Liver / complications,  physiopathology*
Female
Humans
Infant, Newborn
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Male
Obesity / complications,  physiopathology*
Pregnancy
Reproducibility of Results
Risk Factors
Grant Support
ID/Acronym/Agency:
5 T32 DK067009/DK/NIDDK NIH HHS; 5R01DK078645/DK/NIDDK NIH HHS; DK504554/DK/NIDDK NIH HHS; R01 DK062155/DK/NIDDK NIH HHS; R01 DK078645/DK/NIDDK NIH HHS; T32 DK067009/DK/NIDDK NIH HHS; UL1 TR000154/TR/NCATS NIH HHS; UL1TR000154/TR/NCATS NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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