Document Detail


Intragastric pH in postlaparotomy patients--effects of cimetidine.
MedLine Citation:
PMID:  8056397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intragastric pH was continuously monitored in 21 patients who underwent colorectal surgery. Monitoring was started before surgery, and was continued for two days after surgery. Intragastric pH tended to increase during surgery, compared with measurements obtained before and after surgery, but was not affected by the duration of anesthesia or of the surgical procedure, or surgical position. After surgery, patients were divided into two groups: the cimetidine group (10 patients) received intravenous cimetidine 200 mg 4 times a day, while the control group (11 patients) received no treatment. Postoperative intragastric pH was higher than 3.0 throughout the study in the cimetidine group, but was approximately 1.3 in the control group. Upper gastrointestinal bleeding occurred in 2 patients in the control group, with intragastric pH falling abruptly during the bleeding episode. To prevent post-operative upper gastrointestinal bleeding, in addition to the administration of H2-blockers or antacids, appropriate treatments in response to changes in intragastric pH are necessary. Continuous monitoring of intragastric pH in surgical patients is considered to be of clinical importance.
Authors:
S Sakuramoto; H Mieno; Y Sakakibara; Y Hiki; K Saigenji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  41     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-13     Completed Date:  1994-09-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Affiliation:
Department of Surgery, Kitasato University East Hospital, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Cimetidine / therapeutic use*
Colonic Diseases / surgery*
Female
Gastric Acidity Determination*
Gastric Juice / secretion
Gastrointestinal Hemorrhage / prevention & control
Humans
Hydrogen-Ion Concentration
Laparotomy
Male
Middle Aged
Postoperative Complications / prevention & control
Stomach Ulcer / prevention & control
Stress, Physiological / physiopathology
Chemical
Reg. No./Substance:
51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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