Document Detail


Intraepithelial gamma delta T cells are closely associated with apoptotic enterocytes in the bovine intestine.
MedLine Citation:
PMID:  9412736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The T cell population in the intestinal epithelium, comparable in size to the T cell pool in the spleen, is characterized by the predominant distribution of T cells bearing gamma delta T cell receptors. To determine the functional significance of the intraepithelial lymphocytes, we observed gamma delta T cells present in the jejunal epithelium in cattle, in which there is predominance of gamma delta T cells. Immunohistochemistry of frozen sections demonstrated that gamma delta T lymphocytes were densely distributed in the villous epithelium but there were fewer in the lamina propria and they were not present in the crypt epithelium. Ultrastructurally, intraepithelial gamma delta T cells were characterized by possessing electron-dense granules and interdigitating with enterocyte cytoplasm. Enterocytes, which were inserted by processes of intraepithelial lymphocytes or contacted by their cell bodies, showed morphologic changes seen in apoptotic cell death, such as elevated electron density of the cytoplasm and condensation of the chromatin. Apoptotic cells and cell debris were found in macrophages, which gathered in the subepithelial region of villus tips. These findings suggest that in the small intestine of cattle, gamma delta T cells are involved in the renewal of epithelial cells by inducing apoptosis of epithelial cells.
Authors:
Y Suzuki; K Mori; T Iwanaga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of histology and cytology     Volume:  60     ISSN:  0914-9465     ISO Abbreviation:  Arch. Histol. Cytol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-11     Completed Date:  1998-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806082     Medline TA:  Arch Histol Cytol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  319-28     Citation Subset:  IM    
Affiliation:
Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Cattle
Female
Humans
Immunohistochemistry
Intestinal Mucosa / immunology*,  ultrastructure
Intestine, Small / immunology*,  ultrastructure
Macrophages / cytology,  ultrastructure
Microscopy, Electron
Receptors, Antigen, T-Cell, gamma-delta / metabolism*
T-Lymphocytes / cytology*,  metabolism,  ultrastructure
Chemical
Reg. No./Substance:
0/Receptors, Antigen, T-Cell, gamma-delta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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