| Intraepidermal nerve fibre density in cancer patients receiving adjuvant chemotherapy. | |
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MedLine Citation:
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PMID: 22199308 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Chemotherapy-induced neuropathy is a common adverse event in patients receiving vinca alcaloids, platinum derivatives and taxanes. However, the underlying pathogenetic mechanisms have not been completely elucidated. We set up a prospective pilot study on skin biopsies in newly diagnosed cancer patients receiving neurotoxic chemotherapeutic agents as adjuvant treatment in order to study the occurrence of small-fibre pathology and its relationship to clinical symptoms. PATIENTS AND METHODS: Skin biopsies from distal leg were performed in 12 patients before, during and after chemotherapy. Using light microscopy, the intraepidermal nerve fibre (IENF) density was determined from the skin biopsies by counting morphometrically the immunopositive nerves per epidermal area. RESULTS: Reduced IENF density was observed in eight patients at baseline. During the follow-up, the IENF density increased significantly in six patients and remained unchanged in two. In four patients, the IENF density was normal both at baseline and at the end of the follow-up period. Neuropathic symptoms were manifested in nine patients, but no association with the IENF count was found. CONCLUSION: During chemotherapy, results from patients revealed different evolutionary patterns of IENF density, but symptoms and IENF density were not related. |
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Authors:
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Mika J Koskinen; Anna-Liisa Kautio; Maija L Haanpää; Hannu K Haapasalo; Pirkko-L Kellokumpu-Lehtinen; Tiina Saarto; Aki J Hietaharju |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 31 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 4413-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Tampere University Hospital, P.O.Box 2000, FIN-33521 Tampere, Finland. mika.koskinen@pshp.fi. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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