| Intraductal papillary mucinous neoplasm of the pancreas with loss of mismatch repair in a patient with Lynch syndrome. | |
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MedLine Citation:
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PMID: 18987546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a precancerous lesion with a well-described progression to carcinoma. This case report describes a 61-year-old woman with a history significant for multiple cancers and a confirmed germline mutation of MSH2, a mismatch repair gene responsible for Lynch syndrome, who was also found to have an IPMN of the pancreas. Phenotypic manifestations of Lynch syndrome in this patient included multiple adenomas and adenocarcinomas of the colon and also several other Lynch syndrome-associated cancers. The patient's adenocarcinoma of the colon and IPMN of the pancreas showed identical immunohistochemical staining profiles with loss of expression of MSH2 and MSH6 proteins and high levels of microsatellite instability. The immunohistochemical staining and microsatellite instability patterns of the adenocarcinoma of the colon and IPMN gives strong evidence to support the consideration of IPMN as part of the spectrum of lesions found in Lynch syndrome. |
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Authors:
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Jennifer A Sparr; Prathap Bandipalliam; Mark S Redston; Sapna Syngal |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal of surgical pathology Volume: 33 ISSN: 1532-0979 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-02-17 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 309-12 Citation Subset: IM |
Affiliation:
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Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Mucinous
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complications,
genetics*,
pathology Adult Brain Neoplasms / complications Breast Neoplasms / complications Carcinoma, Pancreatic Ductal / complications, genetics*, pathology Carcinoma, Papillary / complications, genetics*, pathology Child Colorectal Neoplasms / complications Colorectal Neoplasms, Hereditary Nonpolyposis / complications, genetics* DNA Mismatch Repair Endometrial Neoplasms / complications Female Germ-Line Mutation Humans Immunohistochemistry Middle Aged MutS Homolog 2 Protein / genetics Ovarian Neoplasms / complications Pancreatic Neoplasms / complications, genetics*, pathology Polymerase Chain Reaction Skin Neoplasms / complications |
| Grant Support | |
ID/Acronym/Agency:
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K24 CA113433-04/CA/NCI NIH HHS; K24-113433//PHS HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.6.1.3/MSH2 protein, human; EC 3.6.1.3/MutS Homolog 2 Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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