Document Detail

Intradialytic parenteral nutrition in malnourished children treated with hemodialysis.
MedLine Citation:
PMID:  11823995     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the feasibility and effectiveness of intradialytic parenteral nutrition (IDPN) in children on hemodialysis. DESIGN: Prospective experimental study with a single intervention group. SETTING: A pediatric hemodialysis unit. SUBJECTS: Four malnourished children on hemodialysis (3 girls and 1 boy) 4 to 18 years of age were studied during a period of 1 year. INTERVENTION: IDPN, which is composed of amino acids (8.5% solution), glucose (as 10% to 15% dextrose), and 20% fat emulsion, was administered at every dialysis session (3 times a week, during 4 hours each time) for 7 to 12 weeks. MAIN OUTCOME MEASURE: Oral caloric intake (evaluated by using a 3-day diet history), dry weight (weight after dialysis), body mass index, percent ideal body weight, total lymphocyte count, and serum levels of albumin before, immediately after cessation of IDPN, and 3 months after cessation of IDPN. RESULTS: Oral caloric intake increased markedly after IDPN administration, from 5 to 63 kcal/kg/d (mean, 33 kcal/kg/d) before IDPN administration to 35 to 177 kcal/kg/d (mean, 86 kcal/kg/d) at the time of cessation. Weight did not change during the treatment period but it did increase from 9.5 to 36.4 kg (mean, 25 kg) to 11 to 39 kg (mean, 26.7 kg) 3 months later. Percent ideal body weight increased from 73% to 88% (mean, 78.5%) to 79% to 90% (mean, 85.1%), and body mass index increased from 12.2 to 15 kg/m(2) (mean, 13.5 kg/m(2)) to 13.4 to 15.5 kg/m(2) (mean, 14.6 kg/m(2)). Total lymphocyte count increased from 538 to 2,041 cells/mm(3) (mean, 1,403 cells/mm(3)) to 724 to 2,884 cells/mm(3) (mean, 2,066 cells/mm(3)). Plasma levels of albumin increased in 1 patient but remained unchanged in others. CONCLUSION: Short-term IDPN treatment may serve as a safe and effective nutritional intervention in malnourished children on hemodialysis.
Irit Krause; Raanan Shamir; Miriam Davidovits; Sigal Frishman; Roxana Cleper; Zahava Gamzo; Irit Poraz; Bella Eisenstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  12     ISSN:  1051-2276     ISO Abbreviation:  J Ren Nutr     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-01     Completed Date:  2002-05-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Copyright Information:
Copyright 2002 by the National Kidney Foundation, Inc.
Nephrology Clinic and Dialysis Unit, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
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MeSH Terms
Child Nutrition Disorders / etiology*,  therapy
Child, Preschool
Energy Intake
Kidney Failure, Chronic / complications,  therapy*
Nutritional Requirements
Nutritional Status
Parenteral Nutrition / methods*
Prospective Studies
Renal Dialysis / adverse effects*
Treatment Outcome
Weight Gain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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