| Intradialytic exercise training reduces oxidative stress and epicardial fat: a pilot study. | |
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MedLine Citation:
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PMID: 20190243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cardiovascular disease (CVD) mortality rates are greatly elevated in chronic kidney disease patients receiving maintenance haemodialysis therapy. The purpose of this study was to evaluate the efficacy of intradialytic endurance exercise training on novel risk factors that may contribute to this excessive CVD risk. METHODS: Seventeen haemodialysis patients were randomized to either an intradialytic exercise training (cycling) group (EX; n = 8) or a non-exercising control group (CON; n = 9) for 4 months. At baseline and following the intervention, we measured serum parameters related to CVD risk and renal function, used echocardiography to measure variables related to cardiac structure and function and assessed physical performance by a validated shuttle walk test. RESULTS: Performance on the shuttle walk test increased by 17% in EX (P < 0.05), but did not change in CON. There was no change in serum lipids or inflammatory markers (C-reactive protein, interleukin-6) in either group. Serum thiobarbituric acid reactive substances, a marker of oxidative stress, were reduced by 38% in EX (P < 0.05), but did not change in CON. In addition, serum alkaline phosphatase (ALP), a putative risk factor for vascular calcification, was reduced by 27% in EX (P < 0.05), but did not change in CON. There was no change in left atrial volume, left ventricular mass or myocardial performance index in either group. However, the thickness of the epicardial fat layer was reduced by 11% in EX (P < 0.05), but did not change in CON. Furthermore, the change in physical performance was inversely correlated to the change in epicardial fat (r = -0.63; P = 0.03). CONCLUSIONS: These results suggest that endurance exercise training may improve CVD risk in haemodialysis patients by decreasing novel risk factors including serum oxidative stress, ALP and epicardial fat. |
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Authors:
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Kenneth R Wilund; Emily J Tomayko; Pei-Tzu Wu; Hae Ryong Chung; Srikanth Vallurupalli; Batlagundu Lakshminarayanan; Bo Fernhall |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-02-26 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 25 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 2695-701 Citation Subset: IM |
Affiliation:
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Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, USA. kwilund@illinois.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Proteins / metabolism C-Reactive Protein / metabolism Cardiovascular Diseases / epidemiology, prevention & control Chronic Disease Echocardiography Exercise / physiology* Female Heart Ventricles / physiopathology, ultrasonography Humans Interleukin-6 / metabolism Kidney Diseases / blood, complications*, therapy* Lipid Metabolism / physiology* Male Middle Aged Oxidative Stress / physiology* Pericardium / physiopathology, ultrasonography* Pilot Projects Renal Dialysis* Risk Factors Thiobarbituric Acid Reactive Substances / metabolism Treatment Outcome Ventricular Remodeling / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Interleukin-6; 0/Thiobarbituric Acid Reactive Substances; 0/alpha2HS glycoprotein; 9007-41-4/C-Reactive Protein |
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