| Intradermal capsaicin causes dose-dependent pain, allodynia, and hyperalgesia in humans. | |
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MedLine Citation:
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PMID: 16984796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intradermal capsaicin is a human pain model that produces reliable pain and sensitization. This model facilitates controlled testing of analgesic efficacy via a crossover design while minimizing confounding variables in clinical pain states and retaining sufficient power with small samples. METHODS: To determine the lowest dose of capsaicin that produces consistent neurosensory measures, we administered 0.1, 1, 10, or 100 microg to healthy volunteers in a blinded manner (N = 19). Pain scores were recorded at 0, 5, 10, 15, and 60 minutes on a visual analog scale from 0 to 100. Areas and intensities of mechanical allodynia (foam brush stimulus) and pinprick hyperalgesia (von Frey test) were quantified at 15 and 60 minutes, as were flare areas. RESULTS: Capsaicin produced dose-dependent increases in spontaneous pain (p = .013), the area and intensity of mechanical allodynia (p = .006 and p < .001, respectively), the area and intensity of pinprick hyperalgesia (p = .010 and p = .014, respectively), and the flare area (p = .010). The 10 microg dose produced greater spontaneous pain than the 1 microg dose (p = .017). The 100 microg dose produced greater spontaneous pain than the 10 microg, but the difference was not statistically significant. CONCLUSION: The 10 and 100 microg capsaicin doses produced robust pain measures across a range of modalities, and lower doses produced minimal effects. Whereas most studies use 100 microg, using a lower dose is reasonable and may facilitate detection of subtle analgesic effects--particularly with nonopioid analgesics--and drugs can be tested in lower doses, minimizing adverse side effects. |
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Authors:
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Graham C Scanlon; Mark S Wallace; J Sorin Ispirescu; Gery Schulteis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of investigative medicine : the official publication of the American Federation for Clinical Research Volume: 54 ISSN: 1081-5589 ISO Abbreviation: J. Investig. Med. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-09-20 Completed Date: 2007-01-04 Revised Date: 2007-12-31 |
Medline Journal Info:
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Nlm Unique ID: 9501229 Medline TA: J Investig Med Country: Canada |
Other Details:
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Languages: eng Pagination: 238-44 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and the Center for Pain and Palliative Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093-0924, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Capsaicin / administration & dosage, pharmacology* Dose-Response Relationship, Drug Female Humans Hyperalgesia / chemically induced* Injections, Intradermal Male Middle Aged Pain / chemically induced* |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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