Document Detail

Intradermal capsaicin causes dose-dependent pain, allodynia, and hyperalgesia in humans.
MedLine Citation:
PMID:  16984796     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intradermal capsaicin is a human pain model that produces reliable pain and sensitization. This model facilitates controlled testing of analgesic efficacy via a crossover design while minimizing confounding variables in clinical pain states and retaining sufficient power with small samples. METHODS: To determine the lowest dose of capsaicin that produces consistent neurosensory measures, we administered 0.1, 1, 10, or 100 microg to healthy volunteers in a blinded manner (N = 19). Pain scores were recorded at 0, 5, 10, 15, and 60 minutes on a visual analog scale from 0 to 100. Areas and intensities of mechanical allodynia (foam brush stimulus) and pinprick hyperalgesia (von Frey test) were quantified at 15 and 60 minutes, as were flare areas. RESULTS: Capsaicin produced dose-dependent increases in spontaneous pain (p = .013), the area and intensity of mechanical allodynia (p = .006 and p < .001, respectively), the area and intensity of pinprick hyperalgesia (p = .010 and p = .014, respectively), and the flare area (p = .010). The 10 microg dose produced greater spontaneous pain than the 1 microg dose (p = .017). The 100 microg dose produced greater spontaneous pain than the 10 microg, but the difference was not statistically significant. CONCLUSION: The 10 and 100 microg capsaicin doses produced robust pain measures across a range of modalities, and lower doses produced minimal effects. Whereas most studies use 100 microg, using a lower dose is reasonable and may facilitate detection of subtle analgesic effects--particularly with nonopioid analgesics--and drugs can be tested in lower doses, minimizing adverse side effects.
Graham C Scanlon; Mark S Wallace; J Sorin Ispirescu; Gery Schulteis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  54     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-09-20     Completed Date:  2007-01-04     Revised Date:  2007-12-31    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  238-44     Citation Subset:  IM    
Department of Anesthesiology and the Center for Pain and Palliative Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093-0924, USA.
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MeSH Terms
Capsaicin / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Hyperalgesia / chemically induced*
Injections, Intradermal
Middle Aged
Pain / chemically induced*
Reg. No./Substance:

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