| Intracytoplasmic sperm injection outcome versus intracytoplasmic morphologically selected sperm injection outcome: a meta-analysis. | |
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MedLine Citation:
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PMID: 20800549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of a modified intracytoplasmic sperm injection (ICSI), called intracytoplasmic morphologically selected sperm injection (IMSI), demonstrated that a profound morphological investigation of the spermatozoon, under the magnification of 6600 x, enables outcome improvement. The aim of this study was to compare ICSI outcome with IMSI outcome. The meta-analysis results demonstrated no significant difference in fertilization rate between ICSI and IMSI groups. However, a significantly improved implantation (odds ratio (OR) 2.72; 95% confidence interval (CI) 1.50-4.95) and pregnancy rate (OR 3.12; 95% CI 1.55-6.26) was observed in IMSI cycles. Moreover, the results showed a significantly decreased miscarriage rate (OR 0.42; 95% CI 0.23-0.78) in IMSI cycles as compared with ICSI cycles. This is the first meta-analysis of published data to evaluate the potential benefits of IMSI. The pooled data of IMSI cycles demonstrate a statistically significant improvement in implantation and pregnancy rates and a statistically significant reduction in miscarriage rates. However, more randomized controlled trials are needed to confirm these results. |
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Authors:
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Amanda Souza Setti; Renata Cristina Ferreira; Daniela Paes de Almeida Ferreira Braga; Rita de Cássia Sávio Figueira; Assumpto Iaconelli; Edson Borges |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Review Date: 2010-06-19 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 21 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: Netherlands |
Other Details:
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Languages: eng Pagination: 450-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Sapientiae Institute-Educational and Research Center in Assisted Reproduction, R. Vieira Maciel, 62. 04503-040 São Paulo, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology Adult Embryo Implantation Female Fertilization in Vitro / methods Humans Male Pregnancy Pregnancy Rate Sperm Injections, Intracytoplasmic / methods* Spermatozoa / ultrastructure* Treatment Outcome |
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