| Intracytoplasmic sperm injection increases embryo fragmentation without affecting clinical outcome. | |
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MedLine Citation:
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PMID: 10955244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine the effect of intracytoplasmic sperm injection (ICSI) on embryo fragmentation and implantation rates in those embryos chosen for transfer compared to conventional in vitro fertilization (IVF). METHODS: We compared 253 infertility patients (71 ICSI and 182 IVF) with respect to age, semen analysis, number of embryos transferred, embryo fragmentation, implantation rate, and pregnancy rate. Embryo fragmentation was determined by one observer at the same laboratory over the entire study period. RESULTS: A statistically significant difference was observed in mean embryo grade between IVF (2.2 +/- 0.84) and ICSI (2.5 +/- 0.77), P = 0.01. Additionally, the IVF patients had significantly more nonfragmented (grade I) embryos compared to the ICSI group, P < 0.01. CONCLUSIONS: These data suggest that ICSI, irrespective of semen parameters, may increase embryo fragmentation and produce fewer nonfragmented grade I embryos while maintaining implantation and pregnancy rates similar to conventional IVF. |
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Authors:
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J L Frattarelli; M P Leondires; B T Miller; J H Segars |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 17 ISSN: 1058-0468 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-11-22 Completed Date: 2001-01-11 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Embryo Implantation Embryo Transfer Embryo, Mammalian* Female Fertilization in Vitro / adverse effects, methods Humans Male Oocytes Pregnancy Pregnancy Rate* Semen Sperm Injections, Intracytoplasmic / adverse effects* |
| Comments/Corrections | |
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