Document Detail

Intracytoplasmic sperm injection combined with preimplantation genetic diagnosis for the prevention of recurrent gestational trophoblastic disease.
MedLine Citation:
PMID:  9159446     Owner:  NLM     Status:  MEDLINE    
A strategy for the prevention of repeated molar pregnancies by using intracytoplasmic sperm injection (ICSI) coupled with preimplantation genetic diagnosis (PGD) with fluorescence in-situ hybridization (FISH) was developed. In this approach, complete moles which arise from dispermic fertilization are avoided by the use of ICSI. ICSI is followed by preimplantation selection against the transfer of 46,XX embryos, thus preventing complete moles resulting from a fertilization of an inactive oocyte, by a haploid X-bearing spermatozoon which subsequently duplicates. Triploid partial moles which arise mainly from dispermic fertilization may also be prevented by ICSI. The preimplantation confirmation of diploidy by FISH guards against triploid partial moles which may result from mechanisms other than dispermic fertilization. The employment of this strategy in an attempt to prevent a repeated event of molar pregnancy in a patient with a history of two previous episodes of gestational trophoblastic disease is reported.
B E Reubinoff; A Lewin; M Verner; A Safran; J G Schenker; D Abeliovich
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  12     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-22     Completed Date:  1997-07-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  805-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Hadassah Ein Kerem Hebrew University Hospital, Jerusalem, Israel.
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MeSH Terms
Embryonic Development*
Genetic Testing / methods*
Hydatidiform Mole / diagnosis,  genetics
In Situ Hybridization, Fluorescence
Neoplasm Recurrence, Local / prevention & control*
Sperm-Ovum Interactions*
Trophoblastic Neoplasms / diagnosis,  genetics*
Uterine Neoplasms / diagnosis,  genetics*

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