Document Detail

Intracytoplasmic inclusion bodies in the chondrocytes of type I lethal achondrogenesis.
MedLine Citation:
PMID:  186383     Owner:  NLM     Status:  MEDLINE    
Lethal achondrogenesis in the past has been frequently confused with achondroplasia. Clinical and radiologic advances in the last decade have led to clear differentiation of this condition from other types of bone dysplasia. It is further separated into two types on the basis of radiographic and pathologic findings. Re-evaluation of the histologic features has led to the recognition of heretofore unrecognized intracytoplasmic inclusion bodies in the chondrocytes of type 1 achondrogenesis. The finding of inclusions strengthens the differentiation of the two types and may have implications for the pathogenesis of the form of chondrodystrophy.
S S Yang; K P Heidelberger; J Bernstein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  7     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-25     Completed Date:  1977-01-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-73     Citation Subset:  IM    
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MeSH Terms
Bone and Bones / abnormalities*,  pathology
Cartilage / pathology
Genetic Diseases, Inborn / pathology*
Inclusion Bodies / ultrastructure*
Infant, Newborn

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