| Intracystic negative pressure may promote bone formation around jaw cyst. | |
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MedLine Citation:
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PMID: 21566878 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The growth and enlargement of jaw cysts are associated with raised intracystic pressure and bone resorption surrounding the cysts. The major bone-resorbing cells are the osteoclasts. They are acting under the influence of local bone-resorbing factors: prostaglandins, proteinases and cytokines. It was found that positive pressure enhanced the expression of IL-1αmRNA and protein in epithelial cells of odontogenic keratocyst, and increased the secretion of matrix metalloproteinase and PGE2 in a co-culture of odontogenic keratocyst fibroblasts and epithelial cells. However, the signal intensities for IL-1αmRNA and protein in the epithelium were significantly decreased after marsupialization which relived intracystic pressure. Experimental study indicated that intermittent negative pressure could promote osteogenesis in human bone marrow-derived stroma cells (BMSCs) in vitro. We propose a hypothesis that bone formation around the cyst of the jaws would be stimulated by intracystic negative pressure. |
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Authors:
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Yi Zhao; Qi-Bing Han; Bing Liu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Shanghai kou qiang yi xue = Shanghai journal of stomatology Volume: 20 ISSN: 1006-7248 ISO Abbreviation: Shanghai Kou Qiang Yi Xue Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-05-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101090220 Medline TA: Shanghai Kou Qiang Yi Xue Country: China |
Other Details:
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Languages: eng Pagination: 217-8 Citation Subset: D; IM |
Affiliation:
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Department of Prosthodontics,School and Hospital of Stomatology, Wuhan University. Wuhan 430079, Hubei Province, China.E-mail:zhao-yi@163.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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