Document Detail

Intracystic negative pressure may promote bone formation around jaw cyst.
MedLine Citation:
PMID:  21566878     Owner:  NLM     Status:  In-Data-Review    
The growth and enlargement of jaw cysts are associated with raised intracystic pressure and bone resorption surrounding the cysts. The major bone-resorbing cells are the osteoclasts. They are acting under the influence of local bone-resorbing factors: prostaglandins, proteinases and cytokines. It was found that positive pressure enhanced the expression of IL-1αmRNA and protein in epithelial cells of odontogenic keratocyst, and increased the secretion of matrix metalloproteinase and PGE2 in a co-culture of odontogenic keratocyst fibroblasts and epithelial cells. However, the signal intensities for IL-1αmRNA and protein in the epithelium were significantly decreased after marsupialization which relived intracystic pressure. Experimental study indicated that intermittent negative pressure could promote osteogenesis in human bone marrow-derived stroma cells (BMSCs) in vitro. We propose a hypothesis that bone formation around the cyst of the jaws would be stimulated by intracystic negative pressure.
Yi Zhao; Qi-Bing Han; Bing Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shanghai kou qiang yi xue = Shanghai journal of stomatology     Volume:  20     ISSN:  1006-7248     ISO Abbreviation:  Shanghai Kou Qiang Yi Xue     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101090220     Medline TA:  Shanghai Kou Qiang Yi Xue     Country:  China    
Other Details:
Languages:  eng     Pagination:  217-8     Citation Subset:  D; IM    
Department of Prosthodontics,School and Hospital of Stomatology, Wuhan University. Wuhan 430079, Hubei Province,
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