Document Detail

Intractable pruritus in HIV infection: immunologic characterization.
MedLine Citation:
PMID:  10321563     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Severe, intractable pruritus, often associated with erythematopapular skin lesions and hypereosinophilia, is a condition observed in some nonatopic, HIV-infected patients. We performed immunovirologic analyses of this condition. METHODS: Immunologic (mitogen-stimulated production of cytokines, tumor necrosis factor-alpha [TNF-alpha], and soluble CD23; serum levels of soluble CD23, ICAM-1, TNF-alpha, IgG, IgE, and IgA) and virologic (HIV viral load) parameters were analyzed in six patients with therapy-resistant pruritus. Hypereosinophilia was present in all these patients. Results were compared to those of seven HIV-seropositive individuals similar to the first one in terms of CD4 counts and clinical staging, but without pruritus. RESULTS: Hypereosinophilia; hyper-IgE and hyper-IgA; augmented interleukin (IL)-4, IL-5, and sCD23; and reduced interferon-gamma production by mitogen-stimulated peripheral blood mononuclear cells (PBMC) were detected when patients with pruritus were compared to HIV controls. HIV viral load was also augmented in patients in whom pruritus was present. CONCLUSIONS: The results suggest that therapy-resistant, intractable pruritus accompanied by hypereosinophilia may be used to define a subset of HIV-seropositive individuals showing prototypic hyperactivation of humoral immunity, and in whom augmented HIV viral load is present.
F Milazzo; S Piconi; D Trabattoni; C Magni; M Coen; A Capetti; M L Fusi; C Parravicini; M Clerici
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  54     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-09-09     Completed Date:  1999-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  266-72     Citation Subset:  IM; X    
Divisione di Malattie Infettive, Ospedale L. Sacco, Milan, Italy.
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MeSH Terms
Cytokines / biosynthesis
HIV / physiology
HIV Infections / complications*,  immunology*,  virology
Immunoglobulin A / blood
Immunoglobulin G / blood
Intercellular Adhesion Molecule-1 / blood
Leukocyte Count
Middle Aged
Pruritus / complications*,  immunology*,  pathology,  virology
RNA, Viral / blood
Receptors, IgE / biosynthesis,  blood
Skin / pathology
Viral Load
Reg. No./Substance:
0/Cytokines; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/RNA, Viral; 0/Receptors, IgE; 126547-89-5/Intercellular Adhesion Molecule-1

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