Document Detail

Intractable Prinzmetal's angina three months after implantation of sirolimus-eluting stent.
MedLine Citation:
PMID:  18987406     Owner:  NLM     Status:  MEDLINE    
Sirolimus-eluting stents (SES) prevent neointimal proliferation and have been widely used to treat stenotic lesions in coronary arteries because of a significant reduction of restenosis in comparison with bare-metal stents. Sirolimus, however, may cause endothelial dysfunction by damage to vascular endothelium or impairing vascular repair. Recent studies report the occurrence of exercise- or acetylcholine-induced coronary vasoconstriction in the vessel segments adjacent to the SES. We report here a clinical case of intractable Prinzmetal's angina 3 months after SES implantation and recommend extended, thorough follow up of patients who have undergone SES implantation.
Mitsuru Abe; Akemi Yoshida; Yoritaka Otsuka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  20     ISSN:  1557-2501     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-06     Completed Date:  2009-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E306-9     Citation Subset:  IM    
Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan. mitsuru@
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MeSH Terms
Angina Pectoris, Variant / etiology*
Drug-Eluting Stents / adverse effects*
Endothelium, Vascular / drug effects*,  physiopathology
Immunosuppressive Agents / administration & dosage,  adverse effects*
Sirolimus / administration & dosage,  adverse effects*
Time Factors
Reg. No./Substance:
0/Immunosuppressive Agents; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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