Document Detail

Intracranial tumor response to respiratory challenges at 3.0 T: impact of different methods to quantify changes in the MR relaxation rate R2*.
MedLine Citation:
PMID:  20578006     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare two DeltaR2* quantification methods for analyzing the response of intracranial tumors to different breathing gases. The determination of changes in the magnetic resonance imaging (MRI) relaxation rate R2* (DeltaR2*), induced by hyperoxic and hypercapnic respiratory challenges, enables the noninvasive assessment of blood oxygenation changes and vasoreactivity. MATERIALS AND METHODS: Sixteen patients with various intracranial tumors were examined at 3.0 T. The response to respiratory challenges was registered using a dynamic multigradient-echo sequence with high temporal and spatial resolution. At each dynamic step, DeltaR2* was derived in two different ways: 1) by subtraction of R2* values obtained from monoexponential decay functions, 2) by computing DeltaR2* echo-wise from signal intensity ratios. The sensitivity for detection of responding voxels and the behavior of the "global" response were investigated. RESULTS: Significantly more responding voxels (about 4%) were found for method (1). The "global" response was independent from the chosen quantification method but showed slightly larger changes (about 6%) when DeltaR2* was derived from method (1). CONCLUSION: Similar results were observed for the two methods, with a slightly higher detection sensitivity of responding voxels when DeltaR2* was obtained from monoexponential approximation.
Andreas Müller; Stefanie Remmele; Ingobert Wenningmann; Hans Clusmann; Frank Träber; Sebastian Flacke; Roy König; Jürgen Gieseke; Winfried A Willinek; Hans H Schild; Petra Mürtz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  32     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Department of Radiology, University of Bonn, Germany.
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MeSH Terms
Brain / metabolism,  pathology
Brain Neoplasms / metabolism,  pathology*,  secondary
Carbon Dioxide / administration & dosage,  metabolism
Echo-Planar Imaging / methods
Glioblastoma / metabolism,  pathology
Hypercapnia / metabolism*
Hyperoxia / metabolism*
Image Processing, Computer-Assisted / methods
Lymphoma, Non-Hodgkin / metabolism,  pathology
Magnetic Resonance Imaging / methods*
Meningioma / metabolism,  pathology
Middle Aged
Oxygen / administration & dosage,  metabolism
Sensitivity and Specificity
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen

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