| Intracranial tumor response to respiratory challenges at 3.0 T: impact of different methods to quantify changes in the MR relaxation rate R2*. | |
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MedLine Citation:
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PMID: 20578006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare two DeltaR2* quantification methods for analyzing the response of intracranial tumors to different breathing gases. The determination of changes in the magnetic resonance imaging (MRI) relaxation rate R2* (DeltaR2*), induced by hyperoxic and hypercapnic respiratory challenges, enables the noninvasive assessment of blood oxygenation changes and vasoreactivity. MATERIALS AND METHODS: Sixteen patients with various intracranial tumors were examined at 3.0 T. The response to respiratory challenges was registered using a dynamic multigradient-echo sequence with high temporal and spatial resolution. At each dynamic step, DeltaR2* was derived in two different ways: 1) by subtraction of R2* values obtained from monoexponential decay functions, 2) by computing DeltaR2* echo-wise from signal intensity ratios. The sensitivity for detection of responding voxels and the behavior of the "global" response were investigated. RESULTS: Significantly more responding voxels (about 4%) were found for method (1). The "global" response was independent from the chosen quantification method but showed slightly larger changes (about 6%) when DeltaR2* was derived from method (1). CONCLUSION: Similar results were observed for the two methods, with a slightly higher detection sensitivity of responding voxels when DeltaR2* was obtained from monoexponential approximation. |
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Authors:
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Andreas Müller; Stefanie Remmele; Ingobert Wenningmann; Hans Clusmann; Frank Träber; Sebastian Flacke; Roy König; Jürgen Gieseke; Winfried A Willinek; Hans H Schild; Petra Mürtz |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 17-23 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, University of Bonn, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / metabolism, pathology Brain Neoplasms / metabolism, pathology*, secondary Carbon Dioxide / administration & dosage, metabolism Echo-Planar Imaging / methods Female Glioblastoma / metabolism, pathology Humans Hypercapnia / metabolism* Hyperoxia / metabolism* Image Processing, Computer-Assisted / methods Lymphoma, Non-Hodgkin / metabolism, pathology Magnetic Resonance Imaging / methods* Male Meningioma / metabolism, pathology Middle Aged Oxygen / administration & dosage, metabolism Respiration* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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