| Intracranial self-administration methodologies. | |
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MedLine Citation:
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PMID: 3317144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracranial drug self-administration (ICSA) offers a relatively new approach for investigating the neurobiological mechanisms involved in brain reinforcement processes. Discrete brain regions responsible for the initiation of neuronal activity associated with the response-contingent delivery of a drug reinforcer can be identified using these procedures since the drug is infused directly into a specific brain locus. In the last decade, several papers have appeared in the literature reporting the self-administration of various substances into a number of brain regions. However, different laboratories often employ diverse methodological procedures to demonstrate ICSA, and this can lead to erroneous conclusions when comparing data from different investigations. This review presents a critical evaluation of the current status of research in this area and suggests behavioral as well as methodological guidelines for future investigations to follow. |
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Authors:
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N E Goeders; J E Smith |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Neuroscience and biobehavioral reviews Volume: 11 ISSN: 0149-7634 ISO Abbreviation: Neurosci Biobehav Rev Publication Date: 1987 |
Date Detail:
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Created Date: 1987-12-22 Completed Date: 1987-12-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 319-29 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Louisiana State University Medical Center, Shreveport 71130. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects* Brain / drug effects, physiology* Cocaine / administration & dosage, pharmacology Dose-Response Relationship, Drug Enkephalin, Methionine / administration & dosage Feeding Behavior / drug effects Motor Activity / drug effects Naloxone / pharmacology Rats Reinforcement (Psychology)* Self Administration / methods* |
| Grant Support | |
ID/Acronym/Agency:
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DA-01999/DA/NIDA NIH HHS; DA-03628/DA/NIDA NIH HHS; DA-03832/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 50-36-2/Cocaine; 58569-55-4/Enkephalin, Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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