| Intracranial pressure increases during exposure to a shock wave. | |
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MedLine Citation:
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PMID: 21091267 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Traumatic brain injuries (TBI) caused by improvised explosive devices (IEDs) affect a significant percentage of surviving soldiers wounded in Iraq and Afghanistan. The extent of a blast TBI, especially initially, is difficult to diagnose, as internal injuries are frequently unrecognized and therefore underestimated, yet problems develop over time. Therefore it is paramount to resolve the physical mechanisms by which critical stresses are inflicted on brain tissue from blast wave encounters with the head. This study recorded direct pressure within the brains of male Sprague-Dawley rats during exposure to blast. The goal was to understand pressure wave dynamics through the brain. In addition, we optimized in vivo methods to ensure accurate measurement of intracranial pressure (ICP). Our results demonstrate that proper sealing techniques lead to a significant increase in ICP values, compared to the outside overpressure generated by the blast. Further, the values seem to have a direct relation to a rat's size and age: heavier, older rats had the highest ICP readings. These findings suggest that a global flexure of the skull by the transient shockwave is an important mechanism of pressure transmission inside the brain. |
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Authors:
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Alessandra Dal Cengio Leonardi; Cynthia A Bir; Dave V Ritzel; Pamela J VandeVord |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of neurotrauma Volume: 28 ISSN: 1557-9042 ISO Abbreviation: J. Neurotrauma Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: United States |
Other Details:
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Languages: eng Pagination: 85-94 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Wayne State University, Detroit, Michigan 48201, USA. pvord@wayne.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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