| Intracranial multifocal dural involvement in multiple myeloma: case report and review of the literature. | |
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MedLine Citation:
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PMID: 20511169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple myeloma is an incurable clonal B-cell malignancy with terminally differentiated plasma cells that accounts for 1% of all malignancies in the United States. It may present with tumors consisting of discrete masses of neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement of myeloma is uncommon and is observed in approximately 1% of cases. It may manifest as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement. Dural involvement of myeloma without parenchymal or leptomeningeal disease is an even rarer occurrence, with only 5 cases reported in the medical literature. There are no established treatment guidelines for CNS myelomatosis; prognosis and literature on the use of treatment modalities for this complication is reviewed herein. |
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Authors:
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Carlos E Méndez; Becky J Hwang; Sylvie Destian; Amitabha Mazumder; Sundar Jagannath; David H Vesole |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical lymphoma, myeloma & leukemia Volume: 10 ISSN: 2152-2669 ISO Abbreviation: Clin Lymphoma Myeloma Leuk Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525386 Medline TA: Clin Lymphoma Myeloma Leuk Country: United States |
Other Details:
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Languages: eng Pagination: 220-3 Citation Subset: IM |
Affiliation:
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Division of Hematology and Oncology, Department of Medicine, St. Vincent's Comprehensive Cancer Center, New York, NY 10011, USA. cmendez@aptiumoncology.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use Boronic Acids / administration & dosage Cisplatin / administration & dosage Cyclophosphamide / administration & dosage Dexamethasone / administration & dosage Doxorubicin / administration & dosage Dura Mater / pathology* Fatal Outcome Humans Male Meningeal Neoplasms / drug therapy, pathology* Middle Aged Multiple Myeloma / drug therapy, pathology*, physiopathology Pyrazines / administration & dosage Thalidomide / administration & dosage, analogs & derivatives |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids; 0/Pyrazines; 0/bortezomib; 15663-27-1/Cisplatin; 191732-72-6/lenalidomide; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 50-18-0/Cyclophosphamide; 50-35-1/Thalidomide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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