Document Detail


Intracranial multifocal dural involvement in multiple myeloma: case report and review of the literature.
MedLine Citation:
PMID:  20511169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple myeloma is an incurable clonal B-cell malignancy with terminally differentiated plasma cells that accounts for 1% of all malignancies in the United States. It may present with tumors consisting of discrete masses of neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement of myeloma is uncommon and is observed in approximately 1% of cases. It may manifest as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement. Dural involvement of myeloma without parenchymal or leptomeningeal disease is an even rarer occurrence, with only 5 cases reported in the medical literature. There are no established treatment guidelines for CNS myelomatosis; prognosis and literature on the use of treatment modalities for this complication is reviewed herein.
Authors:
Carlos E Méndez; Becky J Hwang; Sylvie Destian; Amitabha Mazumder; Sundar Jagannath; David H Vesole
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical lymphoma, myeloma & leukemia     Volume:  10     ISSN:  2152-2669     ISO Abbreviation:  Clin Lymphoma Myeloma Leuk     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525386     Medline TA:  Clin Lymphoma Myeloma Leuk     Country:  United States    
Other Details:
Languages:  eng     Pagination:  220-3     Citation Subset:  IM    
Affiliation:
Division of Hematology and Oncology, Department of Medicine, St. Vincent's Comprehensive Cancer Center, New York, NY 10011, USA. cmendez@aptiumoncology.com
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Boronic Acids / administration & dosage
Cisplatin / administration & dosage
Cyclophosphamide / administration & dosage
Dexamethasone / administration & dosage
Doxorubicin / administration & dosage
Dura Mater / pathology*
Fatal Outcome
Humans
Male
Meningeal Neoplasms / drug therapy,  pathology*
Middle Aged
Multiple Myeloma / drug therapy,  pathology*,  physiopathology
Pyrazines / administration & dosage
Thalidomide / administration & dosage,  analogs & derivatives
Chemical
Reg. No./Substance:
0/Boronic Acids; 0/Pyrazines; 0/bortezomib; 15663-27-1/Cisplatin; 191732-72-6/lenalidomide; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 50-18-0/Cyclophosphamide; 50-35-1/Thalidomide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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