| Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature. | |
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MedLine Citation:
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PMID: 20405323 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We present a case report of a patient recently treated at our institution for an isolated non-small cell lung cancer metastatic lesion to the sella, report the lack of involvement of the pituitary gland in a large single-institution series of treated intracranial parenchymal metastases, and review the pertinent literature. We reviewed cranial imaging studies (CT and MRI) for 935 metastases in 155 patients treated at our institution over the previous 3 years for intracranial metastatic disease. Special attention was paid to the skull base to document the presence of any metastatic disease involving the pituitary gland, infundibular stalk, sella turcica (including anterior and posterior clinoids), or diaphragm sellae. We found no other involvement of the pituitary gland or other sellar structures by metastatic disease in this series. Intracranial metastatic disease rarely involves the pituitary gland and infundibular stalk parenchyma, suggesting that this structure may be safely omitted from the treatment field during WBRT and prophylactic cranial irradiation (PCI). This treatment approach should reduce the late sequelae of treatment to this critical organ. |
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Authors:
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James C Marsh; Shalini Garg; Julie A Wendt; Benjamin T Gielda; Julius V Turian; Arnold M Herskovic |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pituitary Volume: 13 ISSN: 1573-7403 ISO Abbreviation: Pituitary Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814578 Medline TA: Pituitary Country: United States |
Other Details:
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Languages: eng Pagination: 260-5 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Rush University Medical Center, Chicago, IL, USA. james_c_marsh@rush.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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