Document Detail


Intracranial meningioma in children: different from adult forms? A series of 21 cases.
MedLine Citation:
PMID:  20615516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Intracranial meningiomas are very rare in children, comprising only 0.4 to 4.1% of pediatric tumors and only 1.5 to 1.8% to all intracranial meningiomas. The goal of this study of pediatric meningiomas was to establish their epidemiological profile as well as their clinical and radiological features, to assess the long-term outcome, and compare this result with adult meningioma.
PATIENT AND METHODS: We conducted a retrospective study from June 1983 to June 2007; during this period 521 patients underwent surgery for primary meningioma at the Rabat Hospital, Department of Neurosurgery. Twenty-one patients were under 16 years of age (4%). The clinical charts and imaging data were reviewed.
RESULTS: The mean age was 10.3 years (range: 2 to 16 years), with 13 boys and eight girls. In one patient a neurofibromatosis was associated. The mean delay to diagnosis was 4.6 months (range: 1 to 12 months). The most common clinical sign was raised intracranial pressure (90%). Of the meningiomas diagnosed, 47% were convexity meningiomas while 24% were parasagittal and 19% were skull-base meningiomas; in two cases (9.5%) the location was intraventricular. The mean tumor diameter was 6.6 cm (range: 3 to 10 cm). A large cystic component was found in 24% of the cases. Surgery achieved a Simpson grade I resection in 47%; 62% of the tumors were grade I and 24% were grade II based on World Health Organization pathological classification. The mean follow-up period was 33 months (range: 6 to 120 months). The recurrence rate was 33%.
CONCLUSION: Pediatric meningiomas are larger than those found in the adult population; there is a male predominance with high incidence of a cystic component and high-grade meningiomas, thus explaining the increased recurrence rate despite the multimodal treatment.
Authors:
F Lakhdar; Y Arkha; A El Ouahabi; A Melhaoui; L Rifi; S Derraz; A El Khamlichi
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Publication Detail:
Type:  Journal Article     Date:  2010-07-07
Journal Detail:
Title:  Neuro-Chirurgie     Volume:  56     ISSN:  0028-3770     ISO Abbreviation:  Neurochirurgie     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401057     Medline TA:  Neurochirurgie     Country:  France    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
Affiliation:
Department of Neurosurgery, hôpital des Spécialités, Mohamed Vth University School of Medicine, Rabat Institute, BP 6444, 10100 Rabat, Morocco. lakhdar.faycal@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aging / pathology*
Cerebral Angiography
Child
Child, Preschool
Female
Humans
Magnetic Resonance Imaging
Male
Meningioma / epidemiology,  pathology*,  surgery
Neurosurgical Procedures
Retrospective Studies
Sex Factors
Supratentorial Neoplasms / epidemiology,  pathology*,  surgery
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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