Document Detail


Intracranial hemorrhage in newborns with hemophilia: the role of screening radiologic studies in the first 7 days of life.
MedLine Citation:
PMID:  18176189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In newborns with hemophilia, intracranial hemorrhage (ICH) is a potentially life-threatening event and in those who survive, there is a risk of long-term neurologic sequelae. A single-center retrospective chart review was performed to look at the utility of central nervous system screening of babies who were diagnosed with moderate or severe hemophilia in the first 7 days of life. Twenty of the twenty-two eligible babies had either a head ultrasound or computerized tomography of the head performed as soon as possible after the diagnosis of hemophilia was confirmed. ICH was found in 3 of the 20 newborns. All patients with ICH had instrument-assisted deliveries with extracranial signs of bleeding/trauma. On the basis of this series we found screening to be safe and effective in recognizing ICH. As a result of this approach, all ICHs were found when they were radiographically small and before the babies had neurologic symptoms.
Authors:
Angela R Smith; Nicole Leonard; Margaret Heisel Kurth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  30     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-07     Completed Date:  2008-03-18     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
Affiliation:
Department of Pediatric Hematology, University of Minnesota, Minneapolis, MN 55455, USA. smith719@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Female
Hemophilia A / complications,  radiography*,  ultrasonography*
Humans
Infant, Newborn
Intracranial Hemorrhages / complications,  radiography*,  ultrasonography*
Male
Nervous System Diseases / etiology,  radiography,  ultrasonography
Retrospective Studies
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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