Document Detail

Intracranial haemorrhage in the preterm sheep fetus.
MedLine Citation:
PMID:  575326     Owner:  NLM     Status:  MEDLINE    
The germinal layer in the brain of the sheep fetus at 58--85 days of gestation was found to resemble that of the human infant at 28--30 wk of gestation. Experiments were done on 65 exteriorized fetuses to explore the effect of various combinations of asphyxia and raised intravascular pressures in causing bleeding into the germinal layer, ventricles and other parts of the brain. Asphyxia by itself did not produce an increase in the incidence of intracranial hemorrhages when compared with control fetuses. The combination of asphyxia with intermittent increases in arterial or venous pressure, or both, did cause haemorrhages. Large increases in arterial pressure without asphyxia also caused intracranial haemorrhages, whereas increases in venous pressure without asphyxia did not. The types of haemorrhage observed closely resembled those seen in the preterm human infant, although massive intraventricular haemorrhages (IVHs) were rare. We conclude that: (1) the sheep fetus can be used for investigating factors associated with intracranial haemorrhage in the preterm brain; (2) the most effective method of producing haemorrhages into the germinal layer was by a combination of asphyxia with intermittent increases in cerebral intravascular pressure. Similar mechanisms may be at work in the newborn human infant, and could lead to IVH.
M L Reynolds; C A Evans; E O Reynolds; N R Saunders; G M Durbin; J S Wigglesworth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  3     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  163-86     Citation Subset:  IM    
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MeSH Terms
Asphyxia / complications*
Brain / growth & development,  pathology
Cerebral Hemorrhage / etiology*,  pathology
Disease Models, Animal*
Fetal Diseases / etiology*,  pathology
Hypertension / complications*

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