| Intracranial haemorrhage among a population of haemophilic patients in Brazil. | |
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MedLine Citation:
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PMID: 14511296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracranial haemorrhage (ICH) is a common cause of morbidity and mortality in haemophilic patients. The overall incidence of ICH has been reported to range from 2.2% to 7.5% in patients with haemophilia. From 1987 to 2001, 401 haemophilic patients from the Serviço de Hemofilia, Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo were evaluated. The episodes of ICH were documented by CT scan and the anatomic location, clinical presentation, relationship to trauma and clinical factors, including the presence of HIV infection and the presence of inhibitor, were reviewed. Among 401 haemophilic patients, 45 ICH episodes in 35 (8.7%) patients with age ranging from 4 days to 49 years (mean 10.6 years) were observed. A history of recent trauma was documented in 24 (53.3%) cases. Seventeen (37.8%) episodes occurred in more than one site of bleeding, 12 (26.7%) were subdural, seven (15.5%) subarachnoid, four (8.9%) epidural, two (4.4%) intracerebral and one (2.2%) intraventricular. The most frequent symptoms were headache and drowsiness. All patients were submitted to replacement therapy and neurosurgical intervention was performed in eight (17.8%) patients. Despite the treatment, three (8.6%) haemophilia A patients died due to the ICH event and three presented late sequelae. The most important aspect of ICH management is the early replacement therapy in haemophilic patients. This prompt treatment will increase the chances of a better prognosis. Another impact measure consists in the administration of the deficient coagulation factor after every head trauma, even when considered minor. |
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Authors:
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S V Antunes; P Vicari; S Cavalheiro; J O Bordin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Haemophilia : the official journal of the World Federation of Hemophilia Volume: 9 ISSN: 1351-8216 ISO Abbreviation: Haemophilia Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-26 Completed Date: 2003-12-16 Revised Date: 2009-10-21 |
Medline Journal Info:
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Nlm Unique ID: 9442916 Medline TA: Haemophilia Country: England |
Other Details:
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Languages: eng Pagination: 573-7 Citation Subset: IM |
Affiliation:
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Serviço de Hemofilia, Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo, São Paulo, SP, Brazil. sandra@hemato.epm.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Child Child, Preschool Craniocerebral Trauma / complications Factor IX / therapeutic use Factor VIII / therapeutic use HIV Infections / complications Hemophilia A / complications*, drug therapy Hemophilia B / complications*, drug therapy Humans Infant Infant, Newborn Intracranial Hemorrhages / etiology*, radiography Male Middle Aged Recurrence Risk Factors Survival Analysis Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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9001-27-8/Factor VIII; 9001-28-9/Factor IX |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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