Document Detail

Intracranial gradient-echo and spin-echo functional MR angiography in humans.
MedLine Citation:
PMID:  7754004     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the predominance of venous signal intensity at 1.5-T gradient-echo (GRE) functional magnetic resonance (MR) imaging of motor activity and to demonstrate the contribution from task-induced changes in flow velocity to the functional MR imaging signal intensity. MATERIALS AND METHODS: Functional MR imaging of motor activity was performed in healthy volunteers. In a first examination, conventional two-dimensional GRE blood oxygenation level-dependent (BOLD) functional MR imaging techniques were used, and the image planes were carefully positioned with respect to the veins that responded to the motor task. In a second examination, two-dimensional spin-echo (SE) techniques were used, and the image planes were oriented axially and measured in a sequential multisection manner. The areas of hyperintensity on functional MR images were eventually processed by means of maximum intensity projection. RESULTS: Functional MR angiograms were obtained in both examinations. The possibility to generate SE functional MR angiograms demonstrates that venous inflow effects may contribute substantially to signal intensity in conventional two-dimensional GRE BOLD functional MR imaging of motor activity. CONCLUSION: Veins have a substantial role in BOLD functional MR imaging of motor activity.
V Belle; C Delon-Martin; R Massarelli; J Decety; J F Le Bas; A L Benabid; C Segebarth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  195     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-06-20     Completed Date:  1995-06-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  739-46     Citation Subset:  AIM; IM    
INSERM U.318/Groupe d'Application de la RMN à la Neurobiologie, Universitaire de Grenoble, France.
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MeSH Terms
Brain / blood supply
Cerebrovascular Circulation*
Magnetic Resonance Angiography*
Middle Aged
Psychomotor Performance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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