| Intracranial germinoma: clinical and MRI findings in 56 patients. | |
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MedLine Citation:
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PMID: 20665036 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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INTRODUCTION: Intracranial germinoma is a rare malignant tumor, only constituting 0.5-2.0% of all primary intracranial tumors. It usually occurs in children and young adults, it is highly sensitive to radiotherapy or/and chemotherapy, and is potentially curable without operation. To make correct pre-operative diagnosis and spare surgical intervention, we retrospectively reviewed 56 patients in our hospital, and presented clinical findings and MRI characteristics. MATERIALS AND METHODS: We reviewed medical records and magnetic resonance imaging (MRI) of 56 patients. Information regarding sex, age at diagnosis, clinical presentation, duration of symptom, and associated neurologic deficits was noted. The tumor location, number of metastasis, size, margin, involved tissues, and characteristics of signal intensity on MRI were analyzed by two experienced radiologists, respectively. RESULTS: In the series, 57% of intracranial germinoma was located in pineal region, 32% in suprasellar region, and 9% in basal ganglia region. One patient was found germinoma with synchronous lesions in pineal and suprasellar region. Sixty-three percent of patients were male in pineal region, 39% and 100%, respectively, in suprasellar region and basal ganglia region. Age at diagnosis ranged from 3 to 21 years (mean, 12.5 years) with a peak between 10 and 18 years. CONCLUSIONS: Intracranial germinoma has some features in terms of age, sex, clinical presentation, and MRI. These features are in favor of pre-operative diagnosis and thus make for good prognosis. |
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Authors:
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Yajie Wang; Liping Zou; Baoqin Gao |
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Publication Detail:
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Type: Journal Article Date: 2010-07-28 |
Journal Detail:
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Title: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Volume: 26 ISSN: 1433-0350 ISO Abbreviation: Childs Nerv Syst Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8503227 Medline TA: Childs Nerv Syst Country: Germany |
Other Details:
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Languages: eng Pagination: 1773-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Beijing TianTan Hospital, Capital Medical University, Beijing, 100050, China. yajienet@yahoo.com.cn |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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