| Intracranial calcification in early infantile Krabbe disease: nothing new under the sun. | |
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MedLine Citation:
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PMID: 22150413 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report the cases of three children, one male and two females, with a diagnosis of early infantile Krabbe disease demonstrating intracranial calcification on computed tomography (CT). The pattern of calcification was similar in all individuals and involved the internal capsule and cerebral white matter. The presence of calcification caused some diagnostic confusion in what was otherwise a typical clinical and radiological presentation. This finding is not new and has previously been described in publications from the 1980s and 1990s reporting the CT and magnetic resonance imaging appearances of Krabbe disease. With increasing use of magnetic resonance as the first imaging modality for investigation of neurological disorders, characteristic CT appearances may be forgotten. This report serves as a reminder that Krabbe disease should be included in the differential diagnosis of disorders causing intracranial calcification. |
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Authors:
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John H Livingston; Claudio Graziano; Karen Pysden; Yanick J Crow; Santosh R Mordekar; Isabella Moroni; Graziella Uziel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-8 |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: - ISSN: 1469-8749 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© The Authors. Developmental Medicine & Child Neurology © 2011 Mac Keith Press. |
Affiliation:
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Department of Paediatric Neurology, Leeds General Infirmary, Leeds, UK. Medical Genetics Unit, Policlinico S. Orsola-Malpighi, Bologna, Italy. Department of Genetic Medicine, University of Manchester, Manchester Academic Health Science Centre, Central Manchester Foundation Trust University Hospitals, Manchester, UK. Department of Paediatric Neurology, The Ryegate Children's Centre, Sheffield, UK. Department of Child Neurology, Fondazione Istituto Neurologico Besta, Milan, Italy. |
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