Document Detail

Intracranial artery dissection.
MedLine Citation:
PMID:  24824740     Owner:  NLM     Status:  In-Data-Review    
The aim of this narrative review is to evaluate the pathogenesis, clinical features, diagnosis, treatment and prognosis of intracranial artery dissection (IAD). IAD is a rare and often unrecognized cause of stroke or subarachnoid haemorrhage (SAH), especially in young adults. Two types of IAD can be identified: a subintimal or subadventitial dissection. It is suggested that a subintimal dissection results in luminal stenosis, thromboembolism and subsequently cerebral ischaemia, whilst a subadventitial IAD could result in the formation of a pseudo-aneurysm and compression on brainstem or cranial nerves. Rupture of such a dissecting aneurysm causes SAH. The exact cause of IAD remains unknown but several factors are associated with its development. Diagnosis is based on clinical presentation and specific features seen on multimodal neuroimaging. The management of IAD depends on the clinical presentation. In the case of cerebral ischaemia, anticoagulants or antiplatelet agents are used, whilst in the case of SAH endovascular treatment is primarily advocated. Prognosis depends on clinical presentation. Presentation with SAH has a worse prognosis.
T Sikkema; M Uyttenboogaart; O Eshghi; J De Keyser; R Brouns; J M C van Dijk; G J Luijckx
Publication Detail:
Type:  Journal Article     Date:  2014-02-22
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  21     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-05-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  820-6     Citation Subset:  IM    
Copyright Information:
© 2014 The Author(s) European Journal of Neurology © 2014 EAN.
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