| Intracranial arteriovenous malformations treated with LINAC-based conformal radiosurgery: validation of the radiosurgery-based arteriovenous malformation score as a predictor of outcome. | |
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MedLine Citation:
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PMID: 17659161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To validate the radiosurgery-based arteriovenous malformation score (RBAS) as a predictor of outcome in patients with arteriovenous malformations (AVMs) treated with LINAC-based conformal radiosurgery. METHODS: We analysed 40 patients with a mean follow-up of 22 months. One patient (2.5%) pertained to Spetzler-Martin Grade I, 11 (27.5%) to Grade II, 19 (47.5%) to Grade III, eight (20%) to Grade IV and one (2.5%) to grade V. The mean RBAS was 2.0 (range: 0.76-5.56). The mean obliteration prediction index (OPI) and the Karlsson index (KI) were 0.74 (range: 0.2-2.86) and 109.48 (range: 3.0-350.7) respectively. Outcomes were analysed according to the OPI, KI and RBAS. RESULTS: We analysed different cutoff points in the RBAS and found a significant difference to predict the outcome in four scores: 1.2, 1.6, 1.7 and 1.8. In the group with RBAS < or = 1.8, 13 (68%) had an excellent outcome and six (33%) did not, while with RBAS>1.8, seven (32%) had an excellent outcome and 14 (67%) did not (p = 0.02). We did not find any correlation between Spetzler-Martin grading scale or OPI and outcome (p = 0.7 and p = 0.3 respectively). The KI predicted the excellent outcome in 8/9 patients (89%) with KI < or = 27 and in 12/31 patients (39%) with KI>27 (p = 0.08). CONCLUSION: The RBAS seems to be a good predictor of outcome in patients with AVMs treated with LINAC-based conformal radiosurgery as in patients treated with Gamma Knife. It remains only to find the best cutoff point based on a larger series and longer follow-up. |
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Authors:
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Sergio Moreno-Jimenez; Miguel Angel Celis; José Manuel Larraga-Gutierrez; Jose de Jesus Suarez-Campos; Amanda Garcia-Garduñno; Mariana Hernandez-Bojorquez; Guillermo A Gutiérrez-Aceves |
Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: Neurological research Volume: 29 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2008-01-04 Completed Date: 2008-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 712-6 Citation Subset: IM |
Affiliation:
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Department of Radiosurgery, Instituto Nacional de Neurología y Neurocirugía MVS, Insurgentes Sur 3877 Col. La Fama, Tlalpan, México City 14269, Mexico. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Disability Evaluation Female Follow-Up Studies Humans Intracranial Arteriovenous Malformations / diagnosis*, physiopathology, surgery* Male Middle Aged Outcome Assessment (Health Care) / methods* Predictive Value of Tests Radiation Dosage Radiosurgery / statistics & numerical data* Reproducibility of Results Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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