Document Detail


Intracranial arterial occlusion associated with high-activity iodine-125 brachytherapy for glioblastoma.
MedLine Citation:
PMID:  8164061     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe two patients who developed devastating strokes due to intracranial arterial occlusion 15 weeks and 97 weeks following high dose stereotactic iodine-125 brachytherapy for glioblastoma multiforme. In both cases the occlusion was within the implant volume at points receiving 110-281 Gy and there was no other evidence of significant atherosclerosis in the patients. We therefore conclude that these complications were a direct result of the brachytherapy. The phenomenon of radiation-induced occlusion of large cerebral arteries is reviewed.
Authors:
M Bernstein; M Lumley; G Davidson; N Laperriere; P Leung
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  17     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-05-20     Completed Date:  1994-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-60     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, Toronto Hospital, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Arterial Occlusive Diseases / etiology*
Brachytherapy / adverse effects*
Brain Neoplasms / radiotherapy*
Cerebral Arterial Diseases / etiology
Cerebrovascular Disorders / etiology
Glioblastoma / radiotherapy*
Humans
Iodine Radioisotopes / adverse effects*
Male
Middle Aged
Radiotherapy Dosage
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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