| Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. | |
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MedLine Citation:
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PMID: 19731989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults. The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis. To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease). This is the second report of primary intracranial AFH. Additionally, hemorrhage from an intracranial AFH lesion has yet to be reported, and little is known about the radiographic characteristics and biological behavior of these lesions. In this report, the authors describe the case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH. Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern. The diagnosis was confirmed using immunohistochemical and molecular studies. |
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Authors:
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Pawel G Ochalski; James T Edinger; Michael B Horowitz; William R Stetler; Geoffrey H Murdoch; Amin B Kassam; Johnathan A Engh |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 112 ISSN: 1933-0693 ISO Abbreviation: J. Neurosurg. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
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Languages: eng Pagination: 978-82 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiomatosis / complications*, pathology* Cerebral Hemorrhage / complications*, pathology* Diagnosis, Differential Female Histiocytoma, Benign Fibrous / complications*, pathology* Humans Magnetic Resonance Imaging Male Middle Aged Recurrence Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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