| Intracranial aneurysms: from vessel wall pathology to therapeutic approach. | |
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MedLine Citation:
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PMID: 21931350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An aneurysm is a focal dilatation of an arterial blood vessel. Luminal forces, such as high blood flow, shear stress and turbulence, are implicated in the pathogenesis of intracranial aneurysms, and luminal characteristics, such as sac size and morphology, are usually essential to the clinical decision-making process. Despite frequent clinical emphasis on the vessel lumen, however, the pathology underlying the formation, growth and rupture of an aneurysm mainly resides in the vessel wall. Research on the morphology and histopathology of the vessel wall reveals that intracranial aneurysms do not constitute a single disease, but are a shared manifestation of a wide range of diseases, each of which has a unique natural history and optimum therapy. This Review classifies intracranial aneurysms by vessel wall pathology, and demonstrates that understanding the morphology and pathology of this structure is important in determining the therapeutic approach. The article concludes that aneurysms represent a symptom of an underlying vascular disease rather than constituting a disease on their own. |
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Authors:
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Timo Krings; Daniel M Mandell; Tim-Rasmus Kiehl; Sasikhan Geibprasert; Michael Tymianski; Hortensia Alvarez; Karel G terBrugge; Franz-Josef Hans |
Publication Detail:
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Type: Journal Article; Review Date: 2011-09-20 |
Journal Detail:
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Title: Nature reviews. Neurology Volume: 7 ISSN: 1759-4766 ISO Abbreviation: Nat Rev Neurol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-10 Completed Date: 2012-02-01 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 101500072 Medline TA: Nat Rev Neurol Country: England |
Other Details:
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Languages: eng Pagination: 547-59 Citation Subset: IM |
Affiliation:
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Division of Neuroradiology, Toronto Western Hospital, University Health Network, University of Toronto, ON, Canada. timo.krings@uhn.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Vessels
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pathology* Endovascular Procedures / methods* Humans Intracranial Aneurysm / pathology*, therapy* Surgical Instruments |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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