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Intracranial Rosai Dorfman Disease: report of three cases and literature review.
MedLine Citation:
PMID:  22028755     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Rosai-Dorfman Disease (RDD) is a rare idiopathic non-neoplastic histioproliferative disease characterized clinically by massive painless cervical lymphadenopathy, fever and weight loss. Extranodal involvement has also been recognized. Central nervous system (CNS) manifestations are extremely rare and patients with intracranial involvement usually present with clinical and radiological findings suggestive of a meningioma.
CASE DESCRIPTION: We report our experience in the management of three patients with RDD. Two patients had dural based lesions, radiologically in favour of a meningioma, and one patient had a parenchymal lesion suggestive of a tuberculous granuloma. Treatment consisted of total excision in one case, and subtotal excision followed by conventional radiotherapy in two cases. The diagnosis was confirmed by histopathology and immunochemistry which is essential for a definite diagnosis of RDD.
Nigel Peter Symss; Goutham Cugati; Mathabushi C Vasudevan; Ravi Ramamurthi; Anil Pande
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian journal of neurosurgery     Volume:  5     ISSN:  2248-9614     ISO Abbreviation:  Asian J Neurosurg     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2011-10-26     Completed Date:  2011-11-10     Revised Date:  2013-09-16    
Medline Journal Info:
Nlm Unique ID:  101564712     Medline TA:  Asian J Neurosurg     Country:  India    
Other Details:
Languages:  eng     Pagination:  19-30     Citation Subset:  -    
Dr. Achanta Lakshmipathi Neurosurgical Centre, Post Graduate Institute of Neurological Surgery, VHS Hospital, Chennai.
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