Document Detail


Intracranial pressure pulse waveform correlates with aqueductal cerebrospinal fluid stroke volume.
MedLine Citation:
PMID:  22995390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study identifies a novel relationship between cerebrospinal fluid (CSF) stroke volume through the cerebral aqueduct and the characteristic peaks of the intracranial pulse (ICP) waveform. ICP waveform analysis has become much more advanced in recent years; however, clinical practice remains restricted to mean ICP, mainly due to the lack of physiological understanding of the ICP waveform. Therefore, the present study set out to shed some light on the physiological meaning of ICP morphological metrics derived by the morphological clustering and analysis of continuous intracranial pulse (MOCAIP) algorithm by investigating their relationships with a well defined physiological variable, i.e., the stroke volume of CSF through the cerebral aqueduct. Seven patients received both overnight ICP monitoring along with a phase-contrast MRI (PC-MRI) of the cerebral aqueduct to quantify aqueductal stroke volume (ASV). Waveform morphological analysis of the ICP signal was performed by the MOCAIP algorithm. Following extraction of morphological metrics from the ICP signal, nine temporal ICP metrics and two amplitude-based metrics were compared with the ASV via Spearman's rank correlation. Of the nine temporal metrics correlated with the ASV, only the width of the P2 region (ICP-Wi2) reached significance. Furthermore, both ICP pulse pressure amplitude and mean ICP did not reach significance. In this study, we showed the width of the second peak (ICP-Wi2) of an ICP pulse wave is positively related to the volume of CSF movement through the cerebral aqueduct. This finding is an initial step in bridging the gap between ICP waveform morphology research and clinical practice.
Authors:
Robert Hamilton; Kevin Baldwin; Jennifer Fuller; Paul Vespa; Xiao Hu; Marvin Bergsneider
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-20
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-04-29     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1560-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Algorithms
Cerebral Aqueduct / physiopathology*
Cluster Analysis
Female
Humans
Hydrocephalus, Normal Pressure / cerebrospinal fluid,  diagnosis,  physiopathology*
Intracranial Pressure*
Magnetic Resonance Imaging
Male
Monitoring, Physiologic / methods*
Pulsatile Flow*
Pulse Wave Analysis*
Signal Processing, Computer-Assisted
Time Factors
Grant Support
ID/Acronym/Agency:
NS-054881/NS/NINDS NIH HHS; NS-059797/NS/NINDS NIH HHS; NS-066008/NS/NINDS NIH HHS; R01 NS066008/NS/NINDS NIH HHS; R01 NS076738/NS/NINDS NIH HHS
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2013 Jun;114(11):1645   [PMID:  23729634 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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