Document Detail


Intracranial hemodynamics is altered by carotid artery disease and after endarterectomy: a dynamic magnetic resonance angiography study.
MedLine Citation:
PMID:  21350206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Carotid endarterectomy (CEA) has become a routine procedure to treat symptomatic carotid artery disease and reduce the risk of recurrent cerebral ischemic events. The purpose of this study was to use an arterial spin labeling dynamic magnetic resonance angiography technique to characterize intracranial hemodynamics before and after CEA.
METHODS: Thirty-seven carotid artery disease patients participated in this study, of whom 24 underwent magnetic resonance imaging before and after CEA. Seventeen control subjects spanning 5 decades underwent magnetic resonance imaging to assess age-related changes. Hemodynamic metrics (that is, relative time to peak and amplitude) were calculated with a γ-variate model. Linear regression was used to relate carotid artery disease burden to downstream hemodynamics in the circle of Willis.
RESULTS: Relative time to peak increased with age in controls (P<0.020). For patients, relative time to peak was positively correlated with percent stenosis (P<0.050), independent of age. At 1 day after CEA, the middle cerebral artery ipsilateral to the CEA showed significant dynamic magnetic resonance angiography changes: relative time to peak decreased (P<0.017) and the flow amplitude increased (P<0.009). No pre- versus post-CEA changes were significant in the contralateral middle cerebral artery or posterior segments.
CONCLUSIONS: This noninvasive, arterial spin labeling-based method produced time-resolved images that were used to characterize intracranial arterial flow associated with aging, extracranial carotid artery disease, and CEA. Results demonstrate that the technique has the sensitivity to detect hemodynamic changes after CEA.
Authors:
Bradley J MacIntosh; Ediri Sideso; Manus J Donahue; Michael A Chappell; Matthias Günther; Ashok Handa; James Kennedy; Peter Jezzard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-24
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  42     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-29     Completed Date:  2011-05-31     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  979-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Carotid Stenosis / complications*,  physiopathology,  surgery
Cerebral Arteries / pathology
Cerebrovascular Circulation / physiology*
Endarterectomy, Carotid / adverse effects*
Female
Hemodynamics / physiology*
Humans
Magnetic Resonance Angiography* / methods
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
G0802179//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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